Actions of synthetic atrial natriuretic factor on bovine adrenal glomerulosa

Theodore L. Goodfriend; Mary E. Elliott; Steven A. Atlas

doi:10.1016/0024-3205(84)90179-6

Actions of synthetic atrial natriuretic factor on bovine adrenal glomerulosa

Theodore L. Goodfriend, Mary E. Elliott, Steven A. Atlas

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215 Scopus citations

Abstract

Synthetic atrial natriuretic factor (ANF) inhibited aldosterone production by suspensions of bovine adrenal glomerulosa cells. Inhibition by ANF was most pronounced when basal aldosterone production was measured. The effects of angiotensin II (AII), N⁶, O^2′-dibutyryl-adenosine 3′:5′-cyclic monophosphate (dibutyryl cyclic AMP), and elevated potassium were also inhibited by ANF. Inhibition could be partially overcome by high doses of agonist. Inhibition was localized to the early pathway of aldosterogenesis, to a step before cholesterol side-chain cleavage. ANF had no effect on binding of AII to receptors, on the stimulation by AII of phospholipid turnover, or on the alteration by AII of calcium fluxes.

Original language	English
Pages (from-to)	1675-1682
Number of pages	8
Journal	Life Sciences
Volume	35
Issue number	16
DOIs	https://doi.org/10.1016/0024-3205(84)90179-6
State	Published - 15 Oct 1984
Externally published	Yes

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title = "Actions of synthetic atrial natriuretic factor on bovine adrenal glomerulosa",

abstract = "Synthetic atrial natriuretic factor (ANF) inhibited aldosterone production by suspensions of bovine adrenal glomerulosa cells. Inhibition by ANF was most pronounced when basal aldosterone production was measured. The effects of angiotensin II (AII), N6, O2′-dibutyryl-adenosine 3′:5′-cyclic monophosphate (dibutyryl cyclic AMP), and elevated potassium were also inhibited by ANF. Inhibition could be partially overcome by high doses of agonist. Inhibition was localized to the early pathway of aldosterogenesis, to a step before cholesterol side-chain cleavage. ANF had no effect on binding of AII to receptors, on the stimulation by AII of phospholipid turnover, or on the alteration by AII of calcium fluxes.",

author = "Goodfriend, {Theodore L.} and Elliott, {Mary E.} and Atlas, {Steven A.}",

note = "Funding Information: We are grateful for the support and helpful suggestions of Dr. John Laragh and Dr. John Lewicki. We acknowledge the expert technical assistance of Mr. Dennis Ball and Mr. Nicholas Hadjokas. This work was supported by the Veterans A~ninistration and grant HL-18323-SCR and Research Career Development Award HL-O0570 fr~n the National Institutes of Health.",

year = "1984",

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doi = "10.1016/0024-3205(84)90179-6",

language = "English",

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T1 - Actions of synthetic atrial natriuretic factor on bovine adrenal glomerulosa

AU - Goodfriend, Theodore L.

AU - Elliott, Mary E.

AU - Atlas, Steven A.

N1 - Funding Information: We are grateful for the support and helpful suggestions of Dr. John Laragh and Dr. John Lewicki. We acknowledge the expert technical assistance of Mr. Dennis Ball and Mr. Nicholas Hadjokas. This work was supported by the Veterans A~ninistration and grant HL-18323-SCR and Research Career Development Award HL-O0570 fr~n the National Institutes of Health.

PY - 1984/10/15

Y1 - 1984/10/15

N2 - Synthetic atrial natriuretic factor (ANF) inhibited aldosterone production by suspensions of bovine adrenal glomerulosa cells. Inhibition by ANF was most pronounced when basal aldosterone production was measured. The effects of angiotensin II (AII), N6, O2′-dibutyryl-adenosine 3′:5′-cyclic monophosphate (dibutyryl cyclic AMP), and elevated potassium were also inhibited by ANF. Inhibition could be partially overcome by high doses of agonist. Inhibition was localized to the early pathway of aldosterogenesis, to a step before cholesterol side-chain cleavage. ANF had no effect on binding of AII to receptors, on the stimulation by AII of phospholipid turnover, or on the alteration by AII of calcium fluxes.

AB - Synthetic atrial natriuretic factor (ANF) inhibited aldosterone production by suspensions of bovine adrenal glomerulosa cells. Inhibition by ANF was most pronounced when basal aldosterone production was measured. The effects of angiotensin II (AII), N6, O2′-dibutyryl-adenosine 3′:5′-cyclic monophosphate (dibutyryl cyclic AMP), and elevated potassium were also inhibited by ANF. Inhibition could be partially overcome by high doses of agonist. Inhibition was localized to the early pathway of aldosterogenesis, to a step before cholesterol side-chain cleavage. ANF had no effect on binding of AII to receptors, on the stimulation by AII of phospholipid turnover, or on the alteration by AII of calcium fluxes.

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U2 - 10.1016/0024-3205(84)90179-6

DO - 10.1016/0024-3205(84)90179-6

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VL - 35

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EP - 1682

JO - Life Sciences

JF - Life Sciences

IS - 16

ER -

Actions of synthetic atrial natriuretic factor on bovine adrenal glomerulosa

Abstract

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