TY - JOUR
T1 - Action of Biogenic Amines, Amine Oxidase Inhibitors, and Other Agents on Chromatophores of Squid, Loligo pealii.
AU - Rosenblum, William
AU - Zweifach, Benjamin W.
PY - 1959/3
Y1 - 1959/3
N2 - (1) The multicellular system that controls chromatophores of Loligo pealii has been a useful tool for study of smooth muscle function in non-narcotized living animals. (2) Acetylcholine opened chromatophores. The following compounds closed them: Monamine-serotonin. tryptamine HCl, tyramine HCl; indoles-LSD 25; monamine oxidase inhibitors-iproniazid, PIH, Ro-5-0700; autonomic blockers-chlorpromazine; competitors for choline esterase-eserine sulfate. (3) Diamine, histamine dihydrochloride, had no effect. Other monamines, L-lysine and L-alanine, had no effect in comparable dosage. Catechol amines epinephrine and norepinephrine were ineffective. A precursor of serotonin, 5-hydroxytryptophan, had no effect. (4) Closure of chromatophores by an active substance was not reversible by electrical stimulation. (5) Attention is called to the fact that constricting agents all share a common property, that of resonance, and that a number of them are capable of electron donation. (6) Results obtained are consonant with theory that chromatophore control is achieved by an amine-amine oxidase system (closure), opposed by an acetylcholine-choline esterase system (expansion).
AB - (1) The multicellular system that controls chromatophores of Loligo pealii has been a useful tool for study of smooth muscle function in non-narcotized living animals. (2) Acetylcholine opened chromatophores. The following compounds closed them: Monamine-serotonin. tryptamine HCl, tyramine HCl; indoles-LSD 25; monamine oxidase inhibitors-iproniazid, PIH, Ro-5-0700; autonomic blockers-chlorpromazine; competitors for choline esterase-eserine sulfate. (3) Diamine, histamine dihydrochloride, had no effect. Other monamines, L-lysine and L-alanine, had no effect in comparable dosage. Catechol amines epinephrine and norepinephrine were ineffective. A precursor of serotonin, 5-hydroxytryptophan, had no effect. (4) Closure of chromatophores by an active substance was not reversible by electrical stimulation. (5) Attention is called to the fact that constricting agents all share a common property, that of resonance, and that a number of them are capable of electron donation. (6) Results obtained are consonant with theory that chromatophore control is achieved by an amine-amine oxidase system (closure), opposed by an acetylcholine-choline esterase system (expansion).
UR - http://www.scopus.com/inward/record.url?scp=84964159449&partnerID=8YFLogxK
U2 - 10.3181/00379727-100-24658
DO - 10.3181/00379727-100-24658
M3 - Article
C2 - 13634169
AN - SCOPUS:84964159449
SN - 0037-9727
VL - 100
SP - 448
EP - 454
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 3
ER -