Actin dynamics during tumor cell dissemination

Chandrani Mondal, Julie S. Di Martino, Jose Javier Bravo-Cordero

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

16 Scopus citations


The actin cytoskeleton is a dynamic network that regulates cellular behavior from development to disease. By rearranging the actin cytoskeleton, cells are capable of migrating and invading during developmental processes; however, many of these cellular properties are hijacked by cancer cells to escape primary tumors and disseminate to distant organs in the body. In this review article, we highlight recent work describing how cancer cells regulate the actin cytoskeleton to achieve efficient invasion and metastatic colonization. We also review new imaging technologies that are capable of revealing the complex architecture and regulation of the actin cytoskeleton during motility and invasion of tumor cells.

Original languageEnglish
Title of host publicationActin Cytoskeleton in Cancer Progression and Metastasis - Part C
EditorsClément Thomas, Lorenzo Galluzzi
PublisherElsevier Inc.
Number of pages34
ISBN (Print)9780128241387
StatePublished - Jan 2021

Publication series

NameInternational Review of Cell and Molecular Biology
ISSN (Print)1937-6448


  • Actin cytoskeleton
  • Cancer cell motility and dissemination
  • Tumor microenvironment


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