ACTH-Responsive, Dexamethasone-Suppressible Adrenocortical Carcinoma

Elliot J. Rayfield; Leslie I. Rose; John P. Cain; Robert G. Dluhy; Gordon H. Williams

doi:10.1056/NEJM197103182841108

ACTH-Responsive, Dexamethasone-Suppressible Adrenocortical Carcinoma

Elliot J. Rayfield, Leslie I. Rose, John P. Cain, Robert G. Dluhy, Gordon H. Williams

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

ADRENOCORTICAL neoplasms are not thought to be adrenocorticotrophin (ACTH) dependent since they fail to show suppression of 17-hydroxycorticosteroids (17-OHCS) with the administration of 8 mg of dexamethasone per 24 hours.¹ Recently, Kendall and Sloop² described a patient with an adrenocortical adenoma in whom 2 mg of dexamethasone per 24 hours suppressed urinary 17-OHCS excretion from 18 to 3.5 mg per 24 hours. The following report describes a patient with a metastatic adrenocortical carcinoma that physiologically mimicked adrenocortical hyperplasia. Case Report Eight months after right nephroadrenalectomy for adrenocortical “adenoma” with Cushing's syndrome a 70-year-old woman was admitted to the Clinical Center.

Original language	English
Pages (from-to)	591-592
Number of pages	2
Journal	New England Journal of Medicine
Volume	284
Issue number	11
DOIs	https://doi.org/10.1056/NEJM197103182841108
State	Published - 18 Mar 1971

Access to Document

10.1056/NEJM197103182841108

Cite this

@article{59f900a2d4b1480e8a0442361bd12f43,

title = "ACTH-Responsive, Dexamethasone-Suppressible Adrenocortical Carcinoma",

abstract = "ADRENOCORTICAL neoplasms are not thought to be adrenocorticotrophin (ACTH) dependent since they fail to show suppression of 17-hydroxycorticosteroids (17-OHCS) with the administration of 8 mg of dexamethasone per 24 hours.1 Recently, Kendall and Sloop2 described a patient with an adrenocortical adenoma in whom 2 mg of dexamethasone per 24 hours suppressed urinary 17-OHCS excretion from 18 to 3.5 mg per 24 hours. The following report describes a patient with a metastatic adrenocortical carcinoma that physiologically mimicked adrenocortical hyperplasia. Case Report Eight months after right nephroadrenalectomy for adrenocortical “adenoma” with Cushing's syndrome a 70-year-old woman was admitted to the Clinical Center.",

author = "Rayfield, \{Elliot J.\} and Rose, \{Leslie I.\} and Cain, \{John P.\} and Dluhy, \{Robert G.\} and Williams, \{Gordon H.\}",

year = "1971",

month = mar,

day = "18",

doi = "10.1056/NEJM197103182841108",

language = "English",

volume = "284",

pages = "591--592",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

number = "11",

}

TY - JOUR

T1 - ACTH-Responsive, Dexamethasone-Suppressible Adrenocortical Carcinoma

AU - Rayfield, Elliot J.

AU - Rose, Leslie I.

AU - Cain, John P.

AU - Dluhy, Robert G.

AU - Williams, Gordon H.

PY - 1971/3/18

Y1 - 1971/3/18

N2 - ADRENOCORTICAL neoplasms are not thought to be adrenocorticotrophin (ACTH) dependent since they fail to show suppression of 17-hydroxycorticosteroids (17-OHCS) with the administration of 8 mg of dexamethasone per 24 hours.1 Recently, Kendall and Sloop2 described a patient with an adrenocortical adenoma in whom 2 mg of dexamethasone per 24 hours suppressed urinary 17-OHCS excretion from 18 to 3.5 mg per 24 hours. The following report describes a patient with a metastatic adrenocortical carcinoma that physiologically mimicked adrenocortical hyperplasia. Case Report Eight months after right nephroadrenalectomy for adrenocortical “adenoma” with Cushing's syndrome a 70-year-old woman was admitted to the Clinical Center.

AB - ADRENOCORTICAL neoplasms are not thought to be adrenocorticotrophin (ACTH) dependent since they fail to show suppression of 17-hydroxycorticosteroids (17-OHCS) with the administration of 8 mg of dexamethasone per 24 hours.1 Recently, Kendall and Sloop2 described a patient with an adrenocortical adenoma in whom 2 mg of dexamethasone per 24 hours suppressed urinary 17-OHCS excretion from 18 to 3.5 mg per 24 hours. The following report describes a patient with a metastatic adrenocortical carcinoma that physiologically mimicked adrenocortical hyperplasia. Case Report Eight months after right nephroadrenalectomy for adrenocortical “adenoma” with Cushing's syndrome a 70-year-old woman was admitted to the Clinical Center.

UR - https://www.scopus.com/pages/publications/0015230915

U2 - 10.1056/NEJM197103182841108

DO - 10.1056/NEJM197103182841108

M3 - Article

C2 - 4322562

AN - SCOPUS:0015230915

SN - 0028-4793

VL - 284

SP - 591

EP - 592

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 11

ER -

ACTH-Responsive, Dexamethasone-Suppressible Adrenocortical Carcinoma

Abstract

Access to Document

Fingerprint

Cite this