Acid phosphatase-rich granules in human lymphocytes induced by phytohemagglutinin

Rochelle Hirschhorn, J. Martin Kaplan, Arthur F. Goldberg, Kurt Hirschhorn, Gerald Weissmann

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Human lymphocytes, cultured in the presence of phytohemagglutinin, undergo morphologic transformation and subsequent mitosis. Before mitosis (48 to 72 hours), a sharp increase in acid phosphatase activity occurs in cells stimulated with phytohemagglutinin. Histochemical examination of these cells demonstrates that innumerable granules containing acid phosphatase develop in the cytoplasm before mitosis. It is possible that enzymes present in granules which stain for acid phosphatase activity (lysosomelike) may play a role in phytohemagglutinin- stimulated cell division.

Original languageEnglish
Pages (from-to)55-57
Number of pages3
Issue number3653
StatePublished - 1965
Externally publishedYes


Dive into the research topics of 'Acid phosphatase-rich granules in human lymphocytes induced by phytohemagglutinin'. Together they form a unique fingerprint.

Cite this