Achievement of lipid targets with the combination of rosuvastatin and fenofibric acid in patients with type 2 diabetes mellitus

Robert S. Rosenson, Dawn M. Carlson, Maureen T. Kelly, M. Setze Carolyn, Boaz Hirshberg, James C. Stolzenbach, Laura A. Williams

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Objective The objective of this study was to assess the proportion of patients with type 2 diabetes mellitus (T2DM) attaining individual and combined targets of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), non-HDL-C, and apolipoprotein B (ApoB) after treatment with rosuvastatin (R) + fenofibric acid (FA) compared with corresponding-dose R monotherapy. Methods This post hoc analysis evaluated data from the T2DM subset of patients with mixed dyslipidemia (LDL-C ≥ 130 mg/dL, HDL-C < 40/50 mg/dL in men/women, and TG ≥ 150 mg/dL) from 2 randomized studies. Patients included in the analysis (N=456) were treated with R (5, 10, or 20 mg), FA 135 mg, or R (5, 10, or 20 mg) + FA 135 mg for 12 weeks. Attainment of LDL-C < 100 mg/dL, HDL-C > 40/50 mg/dL in men/women, TG < 150 mg/dL, non-HDL-C < 130 mg/dL, ApoB < 90 mg/dL, and the combined targets of these parameters was assessed. Results Treatment with R + FA resulted in a significantly higher proportion of patients achieving optimal levels of HDL-C (46.8% vs. 20.8%, P=0.009 for R 10 mg + FA), TG (60.0% vs. 34.0%, P=0.02 for R 10 mg + FA; 54.0% vs. 26.4%, P=0.005 for R 20 mg + FA), non-HDL-C (55.1% vs. 36.4%, P=0.04 for R 5 mg + FA), ApoB (58.0% vs. 36.4%, P=0.02 for R 5 mg + FA); and the combined targets of LDL-C, HDL-C, and TG (28.3% vs. 8.3%, P=0.02 for R 10 mg + FA) and all 5 parameters (26.1% vs. 8.3%, P=0.03 for R 10 mg + FA) than corresponding-dose R monotherapies. Conclusions A significantly greater proportion of T2DM patients achieved individual and combined lipid targets when treated with the combination of R + FA than corresponding-dose R monotherapies.

Original languageEnglish
Pages (from-to)47-57
Number of pages11
JournalCardiovascular Drugs and Therapy
Volume25
Issue number1
DOIs
StatePublished - Feb 2011

Keywords

  • Dyslipidemia
  • Fibrates
  • Statins

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