Acetylcholine receptors of aneurally cultured human and animal muscle

Valerie Askanas, W. King Engel, Steven P. Ringel, Adam N. Bender

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We describe the diffuse nonjunctional distribution of AChR molecules of aneurally cultured human and animal muscle and the influence of sera from myasthenia gravis patients and rabbits with experimental autoimmune myasthenia gravis on binding of α.BT to diffuse nonjunctional AChR. One-hour incubation of myasthenia gravis sera resulted in blocking of the α-BT-immunoperoxidase staining of their AChRs, while incubation in normal sera did not. Aneurally cultured muscle can aid studies of regenerating fibers in normal muscle compared with those of muscles in neuromuscular diseases, and also act as an environmentally controlled test object for demonstrating the effect of circulating pathogenic factors.

Original languageEnglish
Pages (from-to)1019-1022
Number of pages4
JournalNeurology
Volume27
Issue number11
DOIs
StatePublished - Nov 1977

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