Accelerator mass spectrometry for biomedical research

Karen Brown; Karen H. Dingley; Kenneth W. Turteltaub

doi:10.1016/S0076-6879(05)02014-8

Accelerator mass spectrometry for biomedical research

Karen Brown, Karen H. Dingley, Kenneth W. Turteltaub

Research output: Contribution to journal › Review article › peer-review

54 Scopus citations

Abstract

Accelerator mass spectrometry (AMS) is the most sensitive method for detecting and quantifying rare long-lived isotopes with high precision. In this chapter, we review the principles underlying AMS-based biomedical studies, focusing on important practical considerations and experimental procedures needed for the detection and quantitation of ¹⁴C- and ³H-labeled compounds in various experiment types.

Original language	English
Article number	14
Pages (from-to)	423-443
Number of pages	21
Journal	Methods in Enzymology
Volume	402
DOIs	https://doi.org/10.1016/S0076-6879(05)02014-8
State	Published - 2005
Externally published	Yes

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title = "Accelerator mass spectrometry for biomedical research",

abstract = "Accelerator mass spectrometry (AMS) is the most sensitive method for detecting and quantifying rare long-lived isotopes with high precision. In this chapter, we review the principles underlying AMS-based biomedical studies, focusing on important practical considerations and experimental procedures needed for the detection and quantitation of 14C- and 3H-labeled compounds in various experiment types.",

author = "Karen Brown and Dingley, {Karen H.} and Turteltaub, {Kenneth W.}",

note = "Funding Information: This work was performed under the auspices of the U.S. DOE (W‐7405‐ENG‐48) with support from the National Institutes of Health/National Center for Research Resources (RR13461), DOD Prostate Cancer Program (DAMD17‐03‐1‐0076), and the NCI (CA55861).",

year = "2005",

doi = "10.1016/S0076-6879(05)02014-8",

language = "English",

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pages = "423--443",

journal = "Methods in Enzymology",

issn = "0076-6879",

publisher = "Academic Press Inc.",

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T1 - Accelerator mass spectrometry for biomedical research

AU - Brown, Karen

AU - Dingley, Karen H.

AU - Turteltaub, Kenneth W.

N1 - Funding Information: This work was performed under the auspices of the U.S. DOE (W‐7405‐ENG‐48) with support from the National Institutes of Health/National Center for Research Resources (RR13461), DOD Prostate Cancer Program (DAMD17‐03‐1‐0076), and the NCI (CA55861).

PY - 2005

Y1 - 2005

N2 - Accelerator mass spectrometry (AMS) is the most sensitive method for detecting and quantifying rare long-lived isotopes with high precision. In this chapter, we review the principles underlying AMS-based biomedical studies, focusing on important practical considerations and experimental procedures needed for the detection and quantitation of 14C- and 3H-labeled compounds in various experiment types.

AB - Accelerator mass spectrometry (AMS) is the most sensitive method for detecting and quantifying rare long-lived isotopes with high precision. In this chapter, we review the principles underlying AMS-based biomedical studies, focusing on important practical considerations and experimental procedures needed for the detection and quantitation of 14C- and 3H-labeled compounds in various experiment types.

UR - http://www.scopus.com/inward/record.url?scp=30144437351&partnerID=8YFLogxK

U2 - 10.1016/S0076-6879(05)02014-8

DO - 10.1016/S0076-6879(05)02014-8

M3 - Review article

C2 - 16401518

AN - SCOPUS:30144437351

SN - 0076-6879

VL - 402

SP - 423

EP - 443

JO - Methods in Enzymology

JF - Methods in Enzymology

M1 - 14

ER -

Accelerator mass spectrometry for biomedical research

Abstract

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