Accelerating precision medicine in metastatic prostate cancer

Joaquin Mateo; Rana McKay; Wassim Abida; Rahul Aggarwal; Joshi Alumkal; Ajjai Alva; Felix Feng; Xin Gao; Julie Graff; Maha Hussain; Fatima Karzai; Bruce Montgomery; William Oh; Vaibhav Patel; Dana Rathkopf; Matthew Rettig; Nikolaus Schultz; Matthew Smith; David Solit; Cora Sternberg; Eliezer Van Allen; David VanderWeele; Jake Vinson; Howard R. Soule; Arul Chinnaiyan; Eric Small; Jonathan W. Simons; William Dahut; Andrea K. Miyahira; Himisha Beltran

doi:10.1038/s43018-020-00141-0

Accelerating precision medicine in metastatic prostate cancer

Joaquin Mateo, Rana McKay, Wassim Abida, Rahul Aggarwal, Joshi Alumkal, Ajjai Alva, Felix Feng, Xin Gao, Julie Graff, Maha Hussain, Fatima Karzai, Bruce Montgomery, William Oh, Vaibhav Patel, Dana Rathkopf, Matthew Rettig, Nikolaus Schultz, Matthew Smith, David Solit, Cora SternbergEliezer Van Allen, David VanderWeele, Jake Vinson, Howard R. Soule, Arul Chinnaiyan, Eric Small, Jonathan W. Simons, William Dahut, Andrea K. Miyahira, Himisha Beltran

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48 Scopus citations

Abstract

Despite advances in the screening and treatment of prostate cancer, the therapy options available, particularly for later stages of the disease, remain limited, and the treatment-resistant setting represents a serious unmet medical need. Moreover, disease heterogeneity and disparities in patient access to medical advances result in considerable variability in outcomes across patients. Disease classification based on genomic sequencing is a promising approach for identifying patients whose tumors exhibit actionable targets and for making more informed treatment decisions. Here we discuss how precision oncology can be accelerated to inform broader genomically driven clinical decisions for men with advanced prostate cancer, to inform drug development and, ultimately, to contribute to new treatment paradigms.

Original language	English
Pages (from-to)	1041-1053
Number of pages	13
Journal	Nature Cancer
Volume	1
Issue number	11
DOIs	https://doi.org/10.1038/s43018-020-00141-0
State	Published - Nov 2020

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Mateo, J., McKay, R., Abida, W., Aggarwal, R., Alumkal, J., Alva, A., Feng, F., Gao, X., Graff, J., Hussain, M., Karzai, F., Montgomery, B., Oh, W., Patel, V., Rathkopf, D., Rettig, M., Schultz, N., Smith, M., Solit, D., ... Beltran, H. (2020). Accelerating precision medicine in metastatic prostate cancer. Nature Cancer, 1(11), 1041-1053. https://doi.org/10.1038/s43018-020-00141-0

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title = "Accelerating precision medicine in metastatic prostate cancer",

abstract = "Despite advances in the screening and treatment of prostate cancer, the therapy options available, particularly for later stages of the disease, remain limited, and the treatment-resistant setting represents a serious unmet medical need. Moreover, disease heterogeneity and disparities in patient access to medical advances result in considerable variability in outcomes across patients. Disease classification based on genomic sequencing is a promising approach for identifying patients whose tumors exhibit actionable targets and for making more informed treatment decisions. Here we discuss how precision oncology can be accelerated to inform broader genomically driven clinical decisions for men with advanced prostate cancer, to inform drug development and, ultimately, to contribute to new treatment paradigms.",

author = "Joaquin Mateo and Rana McKay and Wassim Abida and Rahul Aggarwal and Joshi Alumkal and Ajjai Alva and Felix Feng and Xin Gao and Julie Graff and Maha Hussain and Fatima Karzai and Bruce Montgomery and William Oh and Vaibhav Patel and Dana Rathkopf and Matthew Rettig and Nikolaus Schultz and Matthew Smith and David Solit and Cora Sternberg and {Van Allen}, Eliezer and David VanderWeele and Jake Vinson and Soule, {Howard R.} and Arul Chinnaiyan and Eric Small and Simons, {Jonathan W.} and William Dahut and Miyahira, {Andrea K.} and Himisha Beltran",

note = "Publisher Copyright: {\textcopyright} 2020, Springer Nature America, Inc. part of Springer Nature.",

year = "2020",

month = nov,

doi = "10.1038/s43018-020-00141-0",

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Mateo, J, McKay, R, Abida, W, Aggarwal, R, Alumkal, J, Alva, A, Feng, F, Gao, X, Graff, J, Hussain, M, Karzai, F, Montgomery, B, Oh, W, Patel, V, Rathkopf, D, Rettig, M, Schultz, N, Smith, M, Solit, D, Sternberg, C, Van Allen, E, VanderWeele, D, Vinson, J, Soule, HR, Chinnaiyan, A, Small, E, Simons, JW, Dahut, W, Miyahira, AK & Beltran, H 2020, 'Accelerating precision medicine in metastatic prostate cancer', Nature Cancer, vol. 1, no. 11, pp. 1041-1053. https://doi.org/10.1038/s43018-020-00141-0

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AU - Mateo, Joaquin

AU - McKay, Rana

AU - Abida, Wassim

AU - Aggarwal, Rahul

AU - Alumkal, Joshi

AU - Alva, Ajjai

AU - Feng, Felix

AU - Gao, Xin

AU - Graff, Julie

AU - Hussain, Maha

AU - Karzai, Fatima

AU - Montgomery, Bruce

AU - Oh, William

AU - Patel, Vaibhav

AU - Rathkopf, Dana

AU - Rettig, Matthew

AU - Schultz, Nikolaus

AU - Smith, Matthew

AU - Solit, David

AU - Sternberg, Cora

AU - Van Allen, Eliezer

AU - VanderWeele, David

AU - Vinson, Jake

AU - Soule, Howard R.

AU - Chinnaiyan, Arul

AU - Small, Eric

AU - Simons, Jonathan W.

AU - Dahut, William

AU - Miyahira, Andrea K.

AU - Beltran, Himisha

PY - 2020/11

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AB - Despite advances in the screening and treatment of prostate cancer, the therapy options available, particularly for later stages of the disease, remain limited, and the treatment-resistant setting represents a serious unmet medical need. Moreover, disease heterogeneity and disparities in patient access to medical advances result in considerable variability in outcomes across patients. Disease classification based on genomic sequencing is a promising approach for identifying patients whose tumors exhibit actionable targets and for making more informed treatment decisions. Here we discuss how precision oncology can be accelerated to inform broader genomically driven clinical decisions for men with advanced prostate cancer, to inform drug development and, ultimately, to contribute to new treatment paradigms.

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Accelerating precision medicine in metastatic prostate cancer

Abstract

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