@article{57348c4ec30443d49361ea7f8cb26370,
title = "Absent circadian rhythm of proteinuria in hospitalized patients with preeclampsia",
abstract = "Objective. To study the variation of protein excretion in short-interval day-and-night collections in hospitalized preeclamptic patients on continuous bed rest. Methods. We prospectively studied 50 patients admitted to the hospital with the diagnosis of preeclampsia. Urine volumes in 2-, 4-, 12-, and 24-h durations were recorded. Protein concentrations in different volumes of urine were measured. Paired t-test was used to compare the volumes, concentrations, and the total amounts of protein in these samples of different durations. Results. There was no significant difference in the volume of urine and the concentration of proteinuria in the day when compared to night (12-h samples) (p > 0.05). The total amount of protein excreted was comparable for the two durations of samples. For shorter-duration collections (4- and 2-h), the difference in proteinuria between day and night samples remained blunted. Conclusion. This study concludes that there is blunting of variation in protein excretion as observed in short-interval urine collections at different times of the day in hypertensive pregnant patients on continuous bed rest.",
keywords = "Circadian rhythm, Diurnal rhythm, Preeclampsia, Proteinuria",
author = "Shelly Soni and Neelam Aggarwal and Lakhbir Dhaliwal and Sujata Wangkheimayum and Menon, \{Madhav C.\}",
note = "Funding Information: The study was carried out and funded by the Obstetrics and Gynaecology Department of the Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Patients with a systolic blood pressure of more than 140 mmHg or a diastolic blood pressure of more than 90 mmHg and a protein excretion of more than 300 mg in 24 h, admitted in the hospital for the management of preeclampsia, were included in the study. Those with the history of chronic hypertension, underlying kidney disease, and diabetes mellitus were excluded. Patients who were diagnosed to have urinary tract infections or those who were not able to complete the 24-h collection because of obstetric intervention were excluded. Fifty patients who were admitted in the hospital during the period from January 2005 to January 2006, with a diagnosis of preeclampsia, at or beyond 28 weeks of gestation, and who had completed the 24-h urine collection were enrolled in the study. After admission, detailed medical, obstetrical, and menstrual history was taken followed by a complete physical examination. These subjects were investigated and treated according to the existing protocol of the institute for the management of preeclampsia according to its severity. Blood samples were obtained from all the patients, and the markers of severity of preeclampsia including the serum creatinine were measured on admission. Clearance from the ethical committee of the medical center was obtained for the study, and informed consent was taken from all the patients enrolled in the study.",
year = "2012",
month = may,
doi = "10.3109/10641955.2010.507846",
language = "English",
volume = "31",
pages = "300--306",
journal = "Hypertension in Pregnancy",
issn = "1064-1955",
publisher = "Taylor and Francis Ltd.",
number = "2",
}