Absence of the CD44 gene prevents sarcoma metastasis

Georg F. Weber, Roderick T. Bronson, John Ilagan, Harvey Cantor, Rudolf Schmits, Tak W. Mak

Research output: Contribution to journalArticlepeer-review

129 Scopus citations

Abstract

To test the role of the CD44 gene in tumorigenesis, mice with the min mutation of the APC gene or with the tm1 mutation of the p53 gene were crossed with CD44 knockout mice. The absence of CD44 gene products did not affect tumor incidence or survival; however, mice with disruption of the CD44 gene showed virtually aborted metastasis formation of osteosarcomas. This is in agreement with the role attributed to CD44 variants in the spread of cancer. Therefore, CD44 gene products are not essential for tumor incidence and growth but are important in regulating metastasis formation.

Original languageEnglish
Pages (from-to)2281-2286
Number of pages6
JournalCancer Research
Volume62
Issue number8
StatePublished - 15 Apr 2002
Externally publishedYes

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