Absence of secretory endometrium after false-positive home urine luteinizing hormone testing

Peter G. McGovern, Evan R. Myers, Susan Silva, Christos Coutifaris, Sandra A. Carson, Richard S. Legro, William D. Schlaff, Bruce R. Carr, Michael P. Steinkampf, Linda C. Giudice, Phyllis C. Leppert, Michael P. Diamond

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


To examine the proportion of cases with proliferative endometrium on biopsies performed after positive home urine LH testing. Multicenter clinical trial of the usefulness of endometrial biopsy in the evaluation of infertility, with women from fertile and infertile couples randomly assigned to midluteal vs. late luteal phase endometrial sampling. Twelve clinical sites of the National Institutes of Health/National Institute of Child Health and Human Development-sponsored Reproductive Medicine Network. All women in the study had regular menstrual cycles. Fertile volunteers who had delivered a live born infant within the past 2 years without medical intervention were recruited through advertisements at participating sites. Infertile women with regular cycles were recruited from the clinical practices of the sites' physicians. Interview, informed consent, subject-interpreted home urine LH testing, and endometrial biopsy in either the midluteal or late luteal phase. Proportion of cases with proliferative endometrium on biopsy. In both fertile and infertile women, more than 7% of endometrial biopsies performed 7-13 days after a positive home urine LH test revealed proliferative endometrium. Patient interpretation of home urine LH test kits not uncommonly results in false-positive tests. Women planning menstrual cycle testing or procedures related to ovulation may benefit from additional confirmatory testing.

Original languageEnglish
Pages (from-to)1273-1277
Number of pages5
JournalFertility and Sterility
Issue number5
StatePublished - Nov 2004
Externally publishedYes


  • Fertility
  • endometrial biopsy
  • infertility
  • ovulation
  • urine LH tests


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