Absence of Myocardial Involvement After SARS-CoV-2 Vaccination in Asymptomatic Adolescents

Rocío Párraga, Carlos Real, Inés García-Lunar, Gonzalo Pizarro, Javier Sánchez-González, Raquel Diaz-Munoz, Ernesto González-Calvo, Juan Miguel Fernandez-Alvira, Jesús Martínez-Gómez, Rodrigo Fernández-Jiménez

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

This study aimed to evaluate the presence of subclinical myocardial damage in adolescents who were vaccinated against SARS-CoV-2. One hundred twenty asymptomatic adolescents with a mean age of 16.0 ± 0.4 years (51% girls) underwent cardiac magnetic resonance (CMR) imaging. SARS-CoV-2 IgG/IgM antibody testing was performed, and self-reported dates of confirmed SARS-CoV-2 infection and/or vaccination were collected. Participants were classified according to SARS-CoV-2 status as naïve (non-infected and unvaccinated, n = 74), infected (unvaccinated, n = 23), and vaccinated (independently of past infection status, n = 23). Biventricular volumes and ejection fraction and myocardial T2 relaxation time were similar in the three groups. T1 relaxation time was slightly higher in vaccinated adolescents (1249 ± 35 ms) than in naïve and infected participants (1231 ± 30 ms and 1227 ± 29 ms, respectively; p = 0.035), although this difference was considered clinically irrelevant. This observational study found no evidence of relevant subclinical myocardial involvement after SARS-CoV-2 vaccination in asymptomatic adolescents.

Original languageEnglish
Pages (from-to)554-557
Number of pages4
JournalJournal of Cardiovascular Translational Research
Volume17
Issue number3
DOIs
StatePublished - 1 Jun 2024
Externally publishedYes

Keywords

  • Adolescents
  • Cardiovascular magnetic resonance
  • Myocarditis
  • SARS-CoV-2

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