TY - JOUR
T1 - Absence of Myocardial Involvement After SARS-CoV-2 Vaccination in Asymptomatic Adolescents
AU - Párraga, Rocío
AU - Real, Carlos
AU - García-Lunar, Inés
AU - Pizarro, Gonzalo
AU - Sánchez-González, Javier
AU - Diaz-Munoz, Raquel
AU - González-Calvo, Ernesto
AU - Fernandez-Alvira, Juan Miguel
AU - Martínez-Gómez, Jesús
AU - Fernández-Jiménez, Rodrigo
N1 - Publisher Copyright:
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2024/6/1
Y1 - 2024/6/1
N2 - This study aimed to evaluate the presence of subclinical myocardial damage in adolescents who were vaccinated against SARS-CoV-2. One hundred twenty asymptomatic adolescents with a mean age of 16.0 ± 0.4 years (51% girls) underwent cardiac magnetic resonance (CMR) imaging. SARS-CoV-2 IgG/IgM antibody testing was performed, and self-reported dates of confirmed SARS-CoV-2 infection and/or vaccination were collected. Participants were classified according to SARS-CoV-2 status as naïve (non-infected and unvaccinated, n = 74), infected (unvaccinated, n = 23), and vaccinated (independently of past infection status, n = 23). Biventricular volumes and ejection fraction and myocardial T2 relaxation time were similar in the three groups. T1 relaxation time was slightly higher in vaccinated adolescents (1249 ± 35 ms) than in naïve and infected participants (1231 ± 30 ms and 1227 ± 29 ms, respectively; p = 0.035), although this difference was considered clinically irrelevant. This observational study found no evidence of relevant subclinical myocardial involvement after SARS-CoV-2 vaccination in asymptomatic adolescents.
AB - This study aimed to evaluate the presence of subclinical myocardial damage in adolescents who were vaccinated against SARS-CoV-2. One hundred twenty asymptomatic adolescents with a mean age of 16.0 ± 0.4 years (51% girls) underwent cardiac magnetic resonance (CMR) imaging. SARS-CoV-2 IgG/IgM antibody testing was performed, and self-reported dates of confirmed SARS-CoV-2 infection and/or vaccination were collected. Participants were classified according to SARS-CoV-2 status as naïve (non-infected and unvaccinated, n = 74), infected (unvaccinated, n = 23), and vaccinated (independently of past infection status, n = 23). Biventricular volumes and ejection fraction and myocardial T2 relaxation time were similar in the three groups. T1 relaxation time was slightly higher in vaccinated adolescents (1249 ± 35 ms) than in naïve and infected participants (1231 ± 30 ms and 1227 ± 29 ms, respectively; p = 0.035), although this difference was considered clinically irrelevant. This observational study found no evidence of relevant subclinical myocardial involvement after SARS-CoV-2 vaccination in asymptomatic adolescents.
KW - Adolescents
KW - Cardiovascular magnetic resonance
KW - Myocarditis
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85197169708&partnerID=8YFLogxK
U2 - 10.1007/s12265-023-10455-w
DO - 10.1007/s12265-023-10455-w
M3 - Article
C2 - 38112908
AN - SCOPUS:85197169708
SN - 1937-5387
VL - 17
SP - 554
EP - 557
JO - Journal of Cardiovascular Translational Research
JF - Journal of Cardiovascular Translational Research
IS - 3
ER -