Absence of association with DAT1 polymorphism and response to methylphenidate in a sample of adults with ADHD

Eric Mick, Joseph Biederman, Thomas Spencer, Stephen V. Faraone, Pamela Sklar

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46 Scopus citations

Abstract

A polymorphism in the dopamine transporter gene (DAT1) has been previously associated with ADHD and methylphenidate has been hypothesized to block the dopamine transporter. The goal of this study was to examine whether a 40-bp variable number of tandem repeats (VNTR) of DAT1 moderate response and adverse effects associated with methylphenidate treatment of adults with ADHD. Subjects were 106 adults with ADHD enrolled in 6-week randomized placebo-controlled parallel design trials of methylphenidate (OROS and immediate release preparations). There was no evidence of an association between DAT1 VNTR and response to methylphenidate (F(2,100) =0.04, P = 0.9). Similarly, there was no pattern of statistically significant association with DAT1 VNTR and cardiovascular or spontaneously reported adverse effects. We failed to identify an association with DAT1 and the response or tolerability of methylphenidate in adults with ADHD.

Original languageEnglish
Pages (from-to)890-894
Number of pages5
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume141
Issue number8
DOIs
StatePublished - 5 Dec 2006
Externally publishedYes

Keywords

  • Adults
  • Attention-deficit hyperactivity disorder (ADHD)
  • Dopamine transporter (DAT1)
  • Medication response
  • Methylphenidate

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