Absence of 3-methoxy-4-hydroxyphenylethanol in brain

Sherwin Wilk; Betty Zimmerberg

doi:10.1016/0006-2952(73)90376-6

Absence of 3-methoxy-4-hydroxyphenylethanol in brain

Sherwin Wilk
, Betty Zimmerberg

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The occurrence of measurable quantities of 3-methoxy-4-hydroxyphenylethanol (MHPE), a minor metabolite of dopamine, in brain and CSF is controversial. Utilizing gas-liquid chromatography and electron capture detection in a study of trifluoroacetyl and pentafluoropropionyl derivatives of this compound, we were unable to confirm the presence of MHPE in either whole brain or striatal tissue.

Original language	English
Pages (from-to)	623-628
Number of pages	6
Journal	Biochemical Pharmacology
Volume	22
Issue number	5
DOIs	https://doi.org/10.1016/0006-2952(73)90376-6
State	Published - 1 Mar 1973
Externally published	Yes

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title = "Absence of 3-methoxy-4-hydroxyphenylethanol in brain",

abstract = "The occurrence of measurable quantities of 3-methoxy-4-hydroxyphenylethanol (MHPE), a minor metabolite of dopamine, in brain and CSF is controversial. Utilizing gas-liquid chromatography and electron capture detection in a study of trifluoroacetyl and pentafluoropropionyl derivatives of this compound, we were unable to confirm the presence of MHPE in either whole brain or striatal tissue.",

author = "Sherwin Wilk and Betty Zimmerberg",

note = "Funding Information: in part by National Institute of Mental Health Grant MH 21638-01. career development award No. lK04GM4079 3-01. 623",

year = "1973",

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AU - Zimmerberg, Betty

N1 - Funding Information: in part by National Institute of Mental Health Grant MH 21638-01. career development award No. lK04GM4079 3-01. 623

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Y1 - 1973/3/1

N2 - The occurrence of measurable quantities of 3-methoxy-4-hydroxyphenylethanol (MHPE), a minor metabolite of dopamine, in brain and CSF is controversial. Utilizing gas-liquid chromatography and electron capture detection in a study of trifluoroacetyl and pentafluoropropionyl derivatives of this compound, we were unable to confirm the presence of MHPE in either whole brain or striatal tissue.

AB - The occurrence of measurable quantities of 3-methoxy-4-hydroxyphenylethanol (MHPE), a minor metabolite of dopamine, in brain and CSF is controversial. Utilizing gas-liquid chromatography and electron capture detection in a study of trifluoroacetyl and pentafluoropropionyl derivatives of this compound, we were unable to confirm the presence of MHPE in either whole brain or striatal tissue.

UR - https://www.scopus.com/pages/publications/0015597634

U2 - 10.1016/0006-2952(73)90376-6

DO - 10.1016/0006-2952(73)90376-6

M3 - Article

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JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

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ER -

Absence of 3-methoxy-4-hydroxyphenylethanol in brain

Abstract

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