Abrogation of IL-2 dependence by recombinant murine retrovirus containing v-myb

Faina V. Rose; E. Premkumar Reddy

doi:10.1016/0042-6822(92)90519-U

Abrogation of IL-2 dependence by recombinant murine retrovirus containing v-myb

Faina V. Rose
, E. Premkumar Reddy

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Biological consequences of expression of v-myb gene in murine long-term T cell lines (CTLL-2 and HT-2) were studied using murine retroviral vectors. Expression of high levels of v-myb altered responses to interleukin (IL)-2, expression of surface markers, and growth characteristics of these cells. Interestingly, v-myb oncogene brings about growth-factor independence in IL-2-dependent T cell lines with concomitant induction of IL-2 mRNA and downregulation of IL-2 receptor synthesis. These results suggest a role for myb gene products in IL-2 gene expression.

Original language	English
Pages (from-to)	650-656
Number of pages	7
Journal	Virology
Volume	188
Issue number	2
DOIs	https://doi.org/10.1016/0042-6822(92)90519-U
State	Published - Jun 1992
Externally published	Yes

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@article{d8efe70839f34a0383905c71b70df0af,

title = "Abrogation of IL-2 dependence by recombinant murine retrovirus containing v-myb",

abstract = "Biological consequences of expression of v-myb gene in murine long-term T cell lines (CTLL-2 and HT-2) were studied using murine retroviral vectors. Expression of high levels of v-myb altered responses to interleukin (IL)-2, expression of surface markers, and growth characteristics of these cells. Interestingly, v-myb oncogene brings about growth-factor independence in IL-2-dependent T cell lines with concomitant induction of IL-2 mRNA and downregulation of IL-2 receptor synthesis. These results suggest a role for myb gene products in IL-2 gene expression.",

author = "Rose, \{Faina V.\} and \{Premkumar Reddy\}, E.",

note = "Funding Information: We thank Dr. Michael Prystowsky and Dr. John Reed for providing the probes for IL-2 and IL-2R. This work was supported by National Institutes of Health Grant CA 10815.",

year = "1992",

month = jun,

doi = "10.1016/0042-6822(92)90519-U",

language = "English",

volume = "188",

pages = "650--656",

journal = "Virology",

issn = "0042-6822",

publisher = "Academic Press Inc.",

number = "2",

}

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T1 - Abrogation of IL-2 dependence by recombinant murine retrovirus containing v-myb

AU - Rose, Faina V.

AU - Premkumar Reddy, E.

N1 - Funding Information: We thank Dr. Michael Prystowsky and Dr. John Reed for providing the probes for IL-2 and IL-2R. This work was supported by National Institutes of Health Grant CA 10815.

PY - 1992/6

Y1 - 1992/6

N2 - Biological consequences of expression of v-myb gene in murine long-term T cell lines (CTLL-2 and HT-2) were studied using murine retroviral vectors. Expression of high levels of v-myb altered responses to interleukin (IL)-2, expression of surface markers, and growth characteristics of these cells. Interestingly, v-myb oncogene brings about growth-factor independence in IL-2-dependent T cell lines with concomitant induction of IL-2 mRNA and downregulation of IL-2 receptor synthesis. These results suggest a role for myb gene products in IL-2 gene expression.

AB - Biological consequences of expression of v-myb gene in murine long-term T cell lines (CTLL-2 and HT-2) were studied using murine retroviral vectors. Expression of high levels of v-myb altered responses to interleukin (IL)-2, expression of surface markers, and growth characteristics of these cells. Interestingly, v-myb oncogene brings about growth-factor independence in IL-2-dependent T cell lines with concomitant induction of IL-2 mRNA and downregulation of IL-2 receptor synthesis. These results suggest a role for myb gene products in IL-2 gene expression.

UR - https://www.scopus.com/pages/publications/0026717684

U2 - 10.1016/0042-6822(92)90519-U

DO - 10.1016/0042-6822(92)90519-U

M3 - Article

C2 - 1585639

AN - SCOPUS:0026717684

SN - 0042-6822

VL - 188

SP - 650

EP - 656

JO - Virology

JF - Virology

IS - 2

ER -

Abrogation of IL-2 dependence by recombinant murine retrovirus containing v-myb

Abstract

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