Abstract
Biological consequences of expression of v-myb gene in murine long-term T cell lines (CTLL-2 and HT-2) were studied using murine retroviral vectors. Expression of high levels of v-myb altered responses to interleukin (IL)-2, expression of surface markers, and growth characteristics of these cells. Interestingly, v-myb oncogene brings about growth-factor independence in IL-2-dependent T cell lines with concomitant induction of IL-2 mRNA and downregulation of IL-2 receptor synthesis. These results suggest a role for myb gene products in IL-2 gene expression.
Original language | English |
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Pages (from-to) | 650-656 |
Number of pages | 7 |
Journal | Virology |
Volume | 188 |
Issue number | 2 |
DOIs | |
State | Published - Jun 1992 |
Externally published | Yes |