Abrogation of IL-2 dependence by recombinant murine retrovirus containing v-myb

Faina V. Rose, E. Premkumar Reddy

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Biological consequences of expression of v-myb gene in murine long-term T cell lines (CTLL-2 and HT-2) were studied using murine retroviral vectors. Expression of high levels of v-myb altered responses to interleukin (IL)-2, expression of surface markers, and growth characteristics of these cells. Interestingly, v-myb oncogene brings about growth-factor independence in IL-2-dependent T cell lines with concomitant induction of IL-2 mRNA and downregulation of IL-2 receptor synthesis. These results suggest a role for myb gene products in IL-2 gene expression.

Original languageEnglish
Pages (from-to)650-656
Number of pages7
JournalVirology
Volume188
Issue number2
DOIs
StatePublished - Jun 1992
Externally publishedYes

Fingerprint

Dive into the research topics of 'Abrogation of IL-2 dependence by recombinant murine retrovirus containing v-myb'. Together they form a unique fingerprint.

Cite this