TY - JOUR
T1 - ABO blood group and risk of colorectal cancer
AU - Khalili, Hamed
AU - Wolpin, Brian M.
AU - Huang, Edward S.
AU - Giovannucci, Edward L.
AU - Kraft, Peter
AU - Fuchs, Charles S.
AU - Chan, Andrew T.
PY - 2011/5
Y1 - 2011/5
N2 - Background: Recent studies have shown an association between non-O blood group and risk of pancreatic cancer. It is unclear whether this association is observed with other gastrointestinal malignancies, including colorectal cancers. Methods: We examined the relationship between ABO blood group and the risk of incident colorectal cancer in two large prospective cohorts. We calculated HR using Cox proportional hazard modeling while adjusting for known risk factors of colorectal cancer. Results: During 996,779 person-years of follow-up, we documented 1,025 incident cases of colorectal cancers. Compared to individuals with blood group O, the multivariate-adjusted HR were 1.08 (95% CI, 0.94-1.24) for blood group A, 1.20 (95% CI, 1.00-1.45) for blood group B, and 1.08 (95% CI, 0.85-1.36) for blood group AB. Conclusion: In two large prospective cohorts, we did not observe a statistically significant association between ABO blood group and risk of colorectal cancer. Impact: These results do not support an association between ABO blood group and risk of colorectal cancer.
AB - Background: Recent studies have shown an association between non-O blood group and risk of pancreatic cancer. It is unclear whether this association is observed with other gastrointestinal malignancies, including colorectal cancers. Methods: We examined the relationship between ABO blood group and the risk of incident colorectal cancer in two large prospective cohorts. We calculated HR using Cox proportional hazard modeling while adjusting for known risk factors of colorectal cancer. Results: During 996,779 person-years of follow-up, we documented 1,025 incident cases of colorectal cancers. Compared to individuals with blood group O, the multivariate-adjusted HR were 1.08 (95% CI, 0.94-1.24) for blood group A, 1.20 (95% CI, 1.00-1.45) for blood group B, and 1.08 (95% CI, 0.85-1.36) for blood group AB. Conclusion: In two large prospective cohorts, we did not observe a statistically significant association between ABO blood group and risk of colorectal cancer. Impact: These results do not support an association between ABO blood group and risk of colorectal cancer.
UR - http://www.scopus.com/inward/record.url?scp=79955779378&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-10-1250
DO - 10.1158/1055-9965.EPI-10-1250
M3 - Article
C2 - 21415359
AN - SCOPUS:79955779378
SN - 1055-9965
VL - 20
SP - 1017
EP - 1020
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 5
ER -