Abnormalities in the primary affective disorders compared to other tricyclic-responsive disorders

L. J. Siever; T. W. Uhde; T. R. Insel; W. H. Kaye; D. C. Jimerson; C. R. Lake; M. Kafka; S. Targum; L. Murphy

Abnormalities in the primary affective disorders compared to other tricyclic-responsive disorders

L. J. Siever
, T. W. Uhde
, T. R. Insel
, W. H. Kaye
, D. C. Jimerson
, C. R. Lake
, M. Kafka
, S. Targum
, L. Murphy

Research output: Contribution to journal › Article › peer-review

Abstract

These preliminary results raise the possibility that other tricyclic-responsive disorders such as obsessive-compulsive disorder, panic/agoraphobia, and anorexia nervosa may show alterations in noradrenergic activity like those present in patients with affective disorders, although differences may also exist between these disorders. All of these disorders may be characterized by a dysregulation of noradrenergic activity associated with decreased α₂-adrenergic responsiveness. Tricyclic antidepressants might be useful in a variety of these disorders by enhancing the efficiency of the noradrenergic system.

Original language	English
Pages (from-to)	435-436
Number of pages	2
Journal	Psychopharmacology Bulletin
Volume	19
Issue number	3
State	Published - 1983
Externally published	Yes

Cite this

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title = "Abnormalities in the primary affective disorders compared to other tricyclic-responsive disorders",

abstract = "These preliminary results raise the possibility that other tricyclic-responsive disorders such as obsessive-compulsive disorder, panic/agoraphobia, and anorexia nervosa may show alterations in noradrenergic activity like those present in patients with affective disorders, although differences may also exist between these disorders. All of these disorders may be characterized by a dysregulation of noradrenergic activity associated with decreased α2-adrenergic responsiveness. Tricyclic antidepressants might be useful in a variety of these disorders by enhancing the efficiency of the noradrenergic system.",

author = "Siever, \{L. J.\} and Uhde, \{T. W.\} and Insel, \{T. R.\} and Kaye, \{W. H.\} and Jimerson, \{D. C.\} and Lake, \{C. R.\} and M. Kafka and S. Targum and L. Murphy",

year = "1983",

language = "English",

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T1 - Abnormalities in the primary affective disorders compared to other tricyclic-responsive disorders

AU - Siever, L. J.

AU - Uhde, T. W.

AU - Insel, T. R.

AU - Kaye, W. H.

AU - Jimerson, D. C.

AU - Lake, C. R.

AU - Kafka, M.

AU - Targum, S.

AU - Murphy, L.

PY - 1983

Y1 - 1983

N2 - These preliminary results raise the possibility that other tricyclic-responsive disorders such as obsessive-compulsive disorder, panic/agoraphobia, and anorexia nervosa may show alterations in noradrenergic activity like those present in patients with affective disorders, although differences may also exist between these disorders. All of these disorders may be characterized by a dysregulation of noradrenergic activity associated with decreased α2-adrenergic responsiveness. Tricyclic antidepressants might be useful in a variety of these disorders by enhancing the efficiency of the noradrenergic system.

AB - These preliminary results raise the possibility that other tricyclic-responsive disorders such as obsessive-compulsive disorder, panic/agoraphobia, and anorexia nervosa may show alterations in noradrenergic activity like those present in patients with affective disorders, although differences may also exist between these disorders. All of these disorders may be characterized by a dysregulation of noradrenergic activity associated with decreased α2-adrenergic responsiveness. Tricyclic antidepressants might be useful in a variety of these disorders by enhancing the efficiency of the noradrenergic system.

UR - https://www.scopus.com/pages/publications/0020956603

M3 - Article

C2 - 6635119

AN - SCOPUS:0020956603

SN - 0048-5764

VL - 19

SP - 435

EP - 436

JO - Psychopharmacology Bulletin

JF - Psychopharmacology Bulletin

IS - 3

ER -

Abnormalities in the primary affective disorders compared to other tricyclic-responsive disorders

Abstract

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