Abnormal resting state fMRI activity predicts processing speed deficits in first-episode psychosis

Miklos Argyelan, Juan A. Gallego, Delbert G. Robinson, Toshikazu Ikuta, Deepak Sarpal, Majnu John, Peter B. Kingsley, John Kane, Anil K. Malhotra, Philip R. Szeszko

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Little is known regarding the neuropsychological significance of resting state functional magnetic resonance imaging (rs-fMRI) activity early in the course of psychosis. Moreover, no studies have used different approaches for analysis of rs-fMRI activity and examined gray matter thickness in the same cohort. In this study, 41 patients experiencing a first-episode of psychosis (including N=17 who were antipsychotic drug-naive at the time of scanning) and 41 individually age- and sex-matched healthy volunteers completed rs-fMRI and structural MRI exams and neuropsychological assessments. We computed correlation matrices for 266 regions-of-interest across the brain to assess global connectivity. In addition, independent component analysis (ICA) was used to assess group differences in the expression of rs-fMRI activity within 20 predefined publicly available templates. Patients demonstrated lower overall rs-fMRI global connectivity compared with healthy volunteers without associated group differences in gray matter thickness assessed within the same regions-of-interest used in this analysis. Similarly, ICA revealed worse rs-fMRI expression scores across all 20 networks in patients compared with healthy volunteers, with posthoc analyses revealing significant (p<0.05; corrected) abnormalities within the caudate nucleus and planum temporale. Worse processing speed correlated significantly with overall lower global connectivity using the region-of-interest approach and lower expression scores within the planum temporale using ICA. Our findings implicate dysfunction in rs-fMRI activity in first-episode psychosis prior to extensive antipsychotic treatment using different analytic approaches (in the absence of concomitant gray matter structural differences) that predict processing speed.

Original languageEnglish
Pages (from-to)1631-1639
Number of pages9
JournalNeuropsychopharmacology
Volume40
Issue number7
DOIs
StatePublished - 4 Feb 2015
Externally publishedYes

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