TY - JOUR
T1 - Abnormal growth of cultured skin fibroblasts associated with poor premorbid history in schizophrenic patients
AU - Mukherjee, Sukdeb
AU - Mahadik, Sahebarao P.
AU - Schnur, David B.
AU - Laev, Heljo
AU - Reddy, Ravinder
N1 - Funding Information:
This research was supported by NIMH grants MH41961, MH46546, and MH47002, and a grant from the van Ameringen Foundation. The authors thank Ms. Hyacinth Thompson, R.N., and the staff of the Research Division for their assistance with the clinical care of the patients, Ms. Elizabeth Williams for establishing and maintaining the fibroblast cell lines, and Drs. Giovanni Caracci, Paolo Decina, Haranath Parepally, and Elzbieta Wirkowski for their assistance with this project.
PY - 1994/10
Y1 - 1994/10
N2 - The relations of abnormal growth of cultured skin fibroblasts, as manifest in prolonged doubling time, and a history of impaired childhood premorbid functioning, separately for social and school (instrumental) functioning were examined in 22 schizophrenic patients. Prolonged doubling time (>2 weeks) was significantly associated with poorer childhood social functioning, even after controlling for variance due to age, sex, race, and age at onset of illness. Doubling time was not associated with school performance scores. The findings indicate that the cellular or molecular process(es) underlying abnormal growth of skin fibroblasts may be involved in, or associated with, aberrant biological processes that contribute to early dyssocial behavior in schizophrenic patients.
AB - The relations of abnormal growth of cultured skin fibroblasts, as manifest in prolonged doubling time, and a history of impaired childhood premorbid functioning, separately for social and school (instrumental) functioning were examined in 22 schizophrenic patients. Prolonged doubling time (>2 weeks) was significantly associated with poorer childhood social functioning, even after controlling for variance due to age, sex, race, and age at onset of illness. Doubling time was not associated with school performance scores. The findings indicate that the cellular or molecular process(es) underlying abnormal growth of skin fibroblasts may be involved in, or associated with, aberrant biological processes that contribute to early dyssocial behavior in schizophrenic patients.
KW - (Schizophrenia)
KW - Fibroblast
KW - Premorbid functioning
UR - https://www.scopus.com/pages/publications/0027953993
U2 - 10.1016/0920-9964(94)90047-7
DO - 10.1016/0920-9964(94)90047-7
M3 - Article
C2 - 7841136
AN - SCOPUS:0027953993
SN - 0920-9964
VL - 13
SP - 233
EP - 237
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 3
ER -