Abnormal eye movements predict disability in MS: Two-year follow-up

Joy Derwenskus; Janet C. Rucker; Alessandro Serra; John S. Stahl; Deborah L. Downey; Nancy L. Adams; R. John Leigh

doi:10.1196/annals.1325.058

Abnormal eye movements predict disability in MS: Two-year follow-up

Joy Derwenskus, Janet C. Rucker, Alessandro Serra, John S. Stahl, Deborah L. Downey, Nancy L. Adams, R. John Leigh

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

We conducted a two-year follow-up study of 40 patients with MS in whom we had reported that abnormal eye movements (AEM) were associated with greater general disability. AEM patients (17/40) remained significantly (p < .001) more disabled (median EDSS of 7.0) than those with normal eye movements (median EDSS of 5.0). AEM and great disability were associated with abnormal MRI signals in brainstem or cerebellum, where disease may involve control circuits for eye movements as well as descending motor pathways.

Original language	English
Pages (from-to)	521-523
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	1039
DOIs	https://doi.org/10.1196/annals.1325.058
State	Published - 2005
Externally published	Yes

Keywords

Internuclear ophthalmoplegia
Nystagmus
Saccadic dysmetria

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title = "Abnormal eye movements predict disability in MS: Two-year follow-up",

abstract = "We conducted a two-year follow-up study of 40 patients with MS in whom we had reported that abnormal eye movements (AEM) were associated with greater general disability. AEM patients (17/40) remained significantly (p < .001) more disabled (median EDSS of 7.0) than those with normal eye movements (median EDSS of 5.0). AEM and great disability were associated with abnormal MRI signals in brainstem or cerebellum, where disease may involve control circuits for eye movements as well as descending motor pathways.",

keywords = "Internuclear ophthalmoplegia, Nystagmus, Saccadic dysmetria",

author = "Joy Derwenskus and Rucker, \{Janet C.\} and Alessandro Serra and Stahl, \{John S.\} and Downey, \{Deborah L.\} and Adams, \{Nancy L.\} and Leigh, \{R. John\}",

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T1 - Abnormal eye movements predict disability in MS

T2 - Two-year follow-up

AU - Derwenskus, Joy

AU - Rucker, Janet C.

AU - Serra, Alessandro

AU - Stahl, John S.

AU - Downey, Deborah L.

AU - Adams, Nancy L.

AU - Leigh, R. John

PY - 2005

Y1 - 2005

N2 - We conducted a two-year follow-up study of 40 patients with MS in whom we had reported that abnormal eye movements (AEM) were associated with greater general disability. AEM patients (17/40) remained significantly (p < .001) more disabled (median EDSS of 7.0) than those with normal eye movements (median EDSS of 5.0). AEM and great disability were associated with abnormal MRI signals in brainstem or cerebellum, where disease may involve control circuits for eye movements as well as descending motor pathways.

AB - We conducted a two-year follow-up study of 40 patients with MS in whom we had reported that abnormal eye movements (AEM) were associated with greater general disability. AEM patients (17/40) remained significantly (p < .001) more disabled (median EDSS of 7.0) than those with normal eye movements (median EDSS of 5.0). AEM and great disability were associated with abnormal MRI signals in brainstem or cerebellum, where disease may involve control circuits for eye movements as well as descending motor pathways.

KW - Internuclear ophthalmoplegia

KW - Nystagmus

KW - Saccadic dysmetria

UR - https://www.scopus.com/pages/publications/22144490801

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SP - 521

EP - 523

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Abnormal eye movements predict disability in MS: Two-year follow-up

Abstract

Keywords

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