Abstract
Objective The objective of this study was to determine if first- and second-trimester biochemical markers for aneuploidy have an association with adverse pregnancy outcomes in twin gestations. Study Design A retrospective cohort study of patients who presented with dichorionic diamniotic twin gestations was performed. Patients with first-trimester low pregnancy-associated plasma protein A (PAPP-A) or low free β human chorionic gonadotropin (β-hCG), or second-trimester elevated α-fetoprotein (AFP), elevated inhibin A, elevated hCG, or low unconjugated estradiol were identified. The rates of adverse pregnancy outcomes were compared between patients with or without abnormal analytes with p < 0.05 used as significance. Results In this study, 340 pregnancies were included. Patients with a low PAPP-A had an increased risk for delivery < 37 weeks. Patients with an elevated second-trimester hCG had an increased risk for spontaneous delivery < 28 weeks and neonatal intensive care unit (NICU) admission. Patients with an elevated inhibin A had an increased risk of spontaneous delivery at < 37 and NICU admission. Patients with an elevated AFP had an increased risk of a NICU admission. Conclusion Certain abnormal aneuploidy markers are associated with an increased risk of adverse pregnancy outcomes in twin gestations.
Original language | English |
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Pages (from-to) | 1331-1335 |
Number of pages | 5 |
Journal | American Journal of Perinatology |
Volume | 32 |
Issue number | 14 |
DOIs | |
State | Published - 16 Sep 2015 |
Keywords
- adverse outcomes
- analytes
- twins