@article{c462da6349c74e19aa3ec3c08f92196c,
title = "Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate",
abstract = "Chromosomal translocations involving the ERG locus are frequent events in human prostate cancer pathogenesis; however, the biological role of aberrant ERG expression is controversial. Here we show that aberrant expression of ERG is a progression event in prostate tumorigenesis. We find that prostate cancer specimens containing the TMPRSS2-ERG rearrangement are significantly enriched for loss of the tumor suppressor PTEN. In concordance with these findings, transgenic overexpression of ERG in mouse prostate tissue promotes marked acceleration and progression of high-grade prostatic intraepithelial neoplasia (HGPIN) to prostatic adenocarcinoma in a Pten heterozygous background. In vitro overexpression of ERG promotes cell migration, a property necessary for tumorigenesis, without affecting proliferation. ADAMTS1 and CXCR4, two candidate genes strongly associated with cell migration, were upregulated in the presence of ERG overexpression. Thus, ERG has a distinct role in prostate cancer progression and cooperates with PTEN haploinsufficiency to promote progression of HGPIN to invasive adenocarcinoma.",
author = "Carver, \{Brett S.\} and Jennifer Tran and Anuradha Gopalan and Zhenbang Chen and Safa Shaikh and Arkaitz Carracedo and Andrea Alimonti and Caterina Nardella and Shohreh Varmeh and Scardino, \{Peter T.\} and Carlos Cordon-Cardo and William Gerald and Pandolfi, \{Pier Paolo\}",
note = "Funding Information: We are grateful to all members of the Pandolfi laboratory and C. Sawyers and his group for stimulating discussions regarding our study project. We thank P. Romanienko and W. Mark from our genetically engineered mouse core facility for their assistance in generating and genotyping our prostate-specific ERG mouse model. We also thank S. Hayward (Vanderbilt-Ingram Cancer Center) for providing us with the BPH-1 cells used for our experiments, R. Lester at our animal facility for caring for our mice on a daily basis and L. DiSantis for her editorial support. This work was funded through grants from the US National Institutes of Health (R01-CA82328, R01-CA84292, P50-CA92629) and Memorial Sloan Kettering Cancer Center Research in Therapeutics Program in Prostate Cancer award to B.S.C. and P.P.P.",
year = "2009",
month = may,
doi = "10.1038/ng.370",
language = "English",
volume = "41",
pages = "619--624",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Research",
number = "5",
}