Abdominal vagotomy does not block the satiety effect of bombesin in the rat

G. P. Smith; C. Jerome; J. Gibbs

doi:10.1016/S0196-9781(81)80096-4

Abdominal vagotomy does not block the satiety effect of bombesin in the rat

G. P. Smith, C. Jerome, J. Gibbs

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

Bombesin (2-16 μg-kg^-1, intraperitoneally) inhibited food intake in rats after abdominal vagotomy. Since the same vagotomized rats did not respond to the octapeptide of cholecystokinin (1-8 μg-kg^-1, intraperitoneally), these data are decisive evidence (1) that bombesin does not produce satiety by releasing endogenous cholecystokinin and (2) that vagal afferents are not necessary for the satiety effect of bombesin.

Original language	English
Pages (from-to)	409-411
Number of pages	3
Journal	Peptides
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/S0196-9781(81)80096-4
State	Published - 1981
Externally published	Yes

Keywords

Bombesin
Chlecystokinin
Food intake
Gut hormones
Gut peptides
Inhibition of food intake
Peptide hormones
Satiety
Vagotomy

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10.1016/S0196-9781(81)80096-4

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title = "Abdominal vagotomy does not block the satiety effect of bombesin in the rat",

abstract = "Bombesin (2-16 μg-kg-1, intraperitoneally) inhibited food intake in rats after abdominal vagotomy. Since the same vagotomized rats did not respond to the octapeptide of cholecystokinin (1-8 μg-kg-1, intraperitoneally), these data are decisive evidence (1) that bombesin does not produce satiety by releasing endogenous cholecystokinin and (2) that vagal afferents are not necessary for the satiety effect of bombesin.",

keywords = "Bombesin, Chlecystokinin, Food intake, Gut hormones, Gut peptides, Inhibition of food intake, Peptide hormones, Satiety, Vagotomy",

author = "Smith, {G. P.} and C. Jerome and J. Gibbs",

note = "Funding Information: We thank Mrs. Marion Jacobson and Mrs. Nina Conte for typing the manuscript. The research was supported by USPHS grants AM 17240 and MH 15455 and by Career Development Awards AM 70874 to J. G. and MH 00149 to G. P. S.",

year = "1981",

doi = "10.1016/S0196-9781(81)80096-4",

language = "English",

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T1 - Abdominal vagotomy does not block the satiety effect of bombesin in the rat

AU - Smith, G. P.

AU - Jerome, C.

AU - Gibbs, J.

N1 - Funding Information: We thank Mrs. Marion Jacobson and Mrs. Nina Conte for typing the manuscript. The research was supported by USPHS grants AM 17240 and MH 15455 and by Career Development Awards AM 70874 to J. G. and MH 00149 to G. P. S.

PY - 1981

Y1 - 1981

N2 - Bombesin (2-16 μg-kg-1, intraperitoneally) inhibited food intake in rats after abdominal vagotomy. Since the same vagotomized rats did not respond to the octapeptide of cholecystokinin (1-8 μg-kg-1, intraperitoneally), these data are decisive evidence (1) that bombesin does not produce satiety by releasing endogenous cholecystokinin and (2) that vagal afferents are not necessary for the satiety effect of bombesin.

AB - Bombesin (2-16 μg-kg-1, intraperitoneally) inhibited food intake in rats after abdominal vagotomy. Since the same vagotomized rats did not respond to the octapeptide of cholecystokinin (1-8 μg-kg-1, intraperitoneally), these data are decisive evidence (1) that bombesin does not produce satiety by releasing endogenous cholecystokinin and (2) that vagal afferents are not necessary for the satiety effect of bombesin.

KW - Bombesin

KW - Chlecystokinin

KW - Food intake

KW - Gut hormones

KW - Gut peptides

KW - Inhibition of food intake

KW - Peptide hormones

KW - Satiety

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JO - Peptides

JF - Peptides

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ER -

Abdominal vagotomy does not block the satiety effect of bombesin in the rat

Abstract

Keywords

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