A whole genome association study in multiple sclerosis patients from north Portugal

Berta Martins Silva; Theodora Thorlacius; Kjartan Benediktsson; Clara Pereira; Ragnheidur Fossdal; Hjortur H. Jonsson; Ana Silva; Isabel Leite; J. Cerqueira; Paulo P. Costa; Monica Marta; Thomas Foltynie; Stephen Sawcer; Alastair Compston; Aslaug Jonasdottir

doi:10.1016/j.jneuroim.2003.08.024

A whole genome association study in multiple sclerosis patients from north Portugal

Berta Martins Silva, Theodora Thorlacius, Kjartan Benediktsson, Clara Pereira, Ragnheidur Fossdal, Hjortur H. Jonsson, Ana Silva, Isabel Leite, J. Cerqueira, Paulo P. Costa, Monica Marta, Thomas Foltynie, Stephen Sawcer, Alastair Compston, Aslaug Jonasdottir

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Genetic factors are known to influence susceptibility to multiple sclerosis (MS) but the genes involved are largely undefined. Here, we report an association study based on 200 patients and 200 controls from the Porto region in Portugal. A total of 3974 markers were successfully typed from which we have identified 46 markers showing evidence of association. When compared to a physical map three regions were found with two of these markers less than 1.5 Mb apart: chromosomes 6p21.3 (the MHC region), 6q14.1 and 7q34.

Original language	English
Pages (from-to)	116-119
Number of pages	4
Journal	Journal of Neuroimmunology
Volume	143
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2003.08.024
State	Published - Oct 2003
Externally published	Yes

Keywords

Association
DNA pooling
GAMES
Genomic screen
Linkage disequilibrium
Multiple sclerosis

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Silva, B. M., Thorlacius, T., Benediktsson, K., Pereira, C., Fossdal, R., Jonsson, H. H., Silva, A., Leite, I., Cerqueira, J., Costa, P. P., Marta, M., Foltynie, T., Sawcer, S., Compston, A., & Jonasdottir, A. (2003). A whole genome association study in multiple sclerosis patients from north Portugal. Journal of Neuroimmunology, 143(1-2), 116-119. https://doi.org/10.1016/j.jneuroim.2003.08.024

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title = "A whole genome association study in multiple sclerosis patients from north Portugal",

abstract = "Genetic factors are known to influence susceptibility to multiple sclerosis (MS) but the genes involved are largely undefined. Here, we report an association study based on 200 patients and 200 controls from the Porto region in Portugal. A total of 3974 markers were successfully typed from which we have identified 46 markers showing evidence of association. When compared to a physical map three regions were found with two of these markers less than 1.5 Mb apart: chromosomes 6p21.3 (the MHC region), 6q14.1 and 7q34.",

keywords = "Association, DNA pooling, GAMES, Genomic screen, Linkage disequilibrium, Multiple sclerosis",

author = "Silva, {Berta Martins} and Theodora Thorlacius and Kjartan Benediktsson and Clara Pereira and Ragnheidur Fossdal and Jonsson, {Hjortur H.} and Ana Silva and Isabel Leite and J. Cerqueira and Costa, {Paulo P.} and Monica Marta and Thomas Foltynie and Stephen Sawcer and Alastair Compston and Aslaug Jonasdottir",

year = "2003",

month = oct,

doi = "10.1016/j.jneuroim.2003.08.024",

language = "English",

volume = "143",

pages = "116--119",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

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Silva, BM, Thorlacius, T, Benediktsson, K, Pereira, C, Fossdal, R, Jonsson, HH, Silva, A, Leite, I, Cerqueira, J, Costa, PP, Marta, M, Foltynie, T, Sawcer, S, Compston, A & Jonasdottir, A 2003, 'A whole genome association study in multiple sclerosis patients from north Portugal', Journal of Neuroimmunology, vol. 143, no. 1-2, pp. 116-119. https://doi.org/10.1016/j.jneuroim.2003.08.024

TY - JOUR

T1 - A whole genome association study in multiple sclerosis patients from north Portugal

AU - Silva, Berta Martins

AU - Thorlacius, Theodora

AU - Benediktsson, Kjartan

AU - Pereira, Clara

AU - Fossdal, Ragnheidur

AU - Jonsson, Hjortur H.

AU - Silva, Ana

AU - Leite, Isabel

AU - Cerqueira, J.

AU - Costa, Paulo P.

AU - Marta, Monica

AU - Foltynie, Thomas

AU - Sawcer, Stephen

AU - Compston, Alastair

AU - Jonasdottir, Aslaug

PY - 2003/10

Y1 - 2003/10

N2 - Genetic factors are known to influence susceptibility to multiple sclerosis (MS) but the genes involved are largely undefined. Here, we report an association study based on 200 patients and 200 controls from the Porto region in Portugal. A total of 3974 markers were successfully typed from which we have identified 46 markers showing evidence of association. When compared to a physical map three regions were found with two of these markers less than 1.5 Mb apart: chromosomes 6p21.3 (the MHC region), 6q14.1 and 7q34.

AB - Genetic factors are known to influence susceptibility to multiple sclerosis (MS) but the genes involved are largely undefined. Here, we report an association study based on 200 patients and 200 controls from the Porto region in Portugal. A total of 3974 markers were successfully typed from which we have identified 46 markers showing evidence of association. When compared to a physical map three regions were found with two of these markers less than 1.5 Mb apart: chromosomes 6p21.3 (the MHC region), 6q14.1 and 7q34.

KW - Association

KW - DNA pooling

KW - GAMES

KW - Genomic screen

KW - Linkage disequilibrium

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=10744219785&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2003.08.024

DO - 10.1016/j.jneuroim.2003.08.024

M3 - Article

C2 - 14575927

AN - SCOPUS:10744219785

SN - 0165-5728

VL - 143

SP - 116

EP - 119

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

A whole genome association study in multiple sclerosis patients from north Portugal

Abstract

Keywords

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