A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers

Avner Thaler, Moran Artzi, Anat Mirelman, Yael Jacob, Rick C. Helmich, Bart F.L. van Nuenen, Tanya Gurevich, Avi Orr-Urtreger, Karen Marder, Susan Bressman, Bastiaan R. Bloem, Talma Hendler, Nir Giladi, Dafna Ben Bashat, Rachel Saunders-Pullman, Vicki Lynn Shanker, Mark Groves, Christine Palmese, Kaili Maloy Stanley, Akhila IyerJeannie Soto-Valencia, Deborah Raymond, Marta San Luciano, Andres Deik, Matthew James Barrette, Jose Cabbasa, Lawrence Severt, Ann Hunt, Naomi Lubarr, Rivka Sachdev, Sara Lewis, Laurie Ozelius, Roy Alcalay, Stanley Fahn, Lucien Cote, Paul Greene, Cheryl Waters, Pietro Mazzoni, Blair Ford, Elan Louis, Oren Levy, Ming Xin Tang, Brian Rakitin, Helen Mejia, Ernest Roos, Martha Orbe Riley, Llency Rosado, Carol Moskowitz, Tsvyatko Dorovski, Lorraine Clark, Xinmin Liu, Sergey Kisselev, Itsik Peer, Vladimir Vacic, Yaacov Balash, Shabtai Hertzel, Ziv Gan Or, Anat Bar Shira, Mali Gana Weiss, Hila Kobo, Noa Bregman, Meir Kestenbaum, Hedva Lehrman, Einat Even Sapir, Shiran Levy, Kira Yasinovsky, Anat Shkedy, Maayan Zelis

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Background: Patients with Parkinson's disease have reduced gray matter volume and fractional anisotropy in both cortical and sub-cortical structures, yet changes in the pre-motor phase of the disease are unknown. Methods: A comprehensive imaging study using voxel-based morphometry and diffusion tensor imaging tract-based spatial statistics analysis was performed on 64 Ashkenazi Jewish asymptomatic first degree relatives of patients with Parkinson's disease (30 mutation carriers), who carry the G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene. Results: No between-group differences in gray matter volume could be noted in either whole-brain or volume-of-interest analysis. Diffusion tensor imaging analysis did not identify group differences in white matter areas, and volume-of-interest analysis identified no differences in diffusivity parameters in Parkinson's disease-related structures. Conclusions: G2019S carriers do not manifest changes in gray matter volume or diffusivity parameters in Parkinson's disease-related structures prior to the appearance of motor symptoms.

Original languageEnglish
Pages (from-to)823-827
Number of pages5
JournalMovement Disorders
Issue number6
StatePublished - May 2014
Externally publishedYes


  • Diffusion tensor imaging
  • G2019S
  • LRRK2
  • Magnetic resonance imaging
  • Parkinson's disease
  • Voxel-based morphometry


Dive into the research topics of 'A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers'. Together they form a unique fingerprint.

Cite this