Abstract
The discovery that RNA viruses, lacking any DNA intermediate, can be engineered to express both coding and noncoding RNAs suggests that this platform may have therapeutic value as a delivery vehicle. Here we illustrate that a self-replicating, noninfectious RNA, modeled on influenza virus, provides one such example of a versatile in vivo delivery system for silencing and/or expressing a desired RNA for therapeutic purposes.
| Original language | English |
|---|---|
| Pages (from-to) | 2333-2336 |
| Number of pages | 4 |
| Journal | Journal of Virology |
| Volume | 88 |
| Issue number | 4 |
| DOIs | |
| State | Published - Feb 2014 |