A variant t(X;15)(p11;q22) translocation in acute promyelocytic leukemia

Arun Srivastava; Nyla Heerema; Richard C. Lauer; Piruz Nahreini; H. Scott Boswell; Ronald Hoffman; Asok C. Antony

doi:10.1016/0165-4608(87)90031-8

A variant t(X;15)(p11;q22) translocation in acute promyelocytic leukemia

Arun Srivastava, Nyla Heerema, Richard C. Lauer, Piruz Nahreini, H. Scott Boswell, Ronald Hoffman, Asok C. Antony

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Abstract

Nonrandom reciprocal translocations involving chromosomes #15 and #17 are characteristic anomalies in a great majority of cases of acute promyelocytic leukemia (APL). Other complex translocations in APL that invariably involve chromosome #17 also have been described. We describe a patient with clinical and morphologic characteristics of APL but with a previously undescribed acquired karyotype, t(X;15)(p11;q22). This is the first translocation in APL described in which chromosome #17 is not involved. Although a comparative structure/function analysis of potentially relevant genes to the translocation breakpoints in both t(X;15) and t(15;17) APL showed no major alterations, the enhanced expression of the c-Kiras oncogene observed in t(X;15) APL supports the concept of heterogeneity in APL at the cytogenetic and molecular levels.

Original language	English
Pages (from-to)	65-74
Number of pages	10
Journal	Cancer Genetics and Cytogenetics
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(87)90031-8
State	Published - Nov 1987
Externally published	Yes

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title = "A variant t(X;15)(p11;q22) translocation in acute promyelocytic leukemia",

abstract = "Nonrandom reciprocal translocations involving chromosomes \#15 and \#17 are characteristic anomalies in a great majority of cases of acute promyelocytic leukemia (APL). Other complex translocations in APL that invariably involve chromosome \#17 also have been described. We describe a patient with clinical and morphologic characteristics of APL but with a previously undescribed acquired karyotype, t(X;15)(p11;q22). This is the first translocation in APL described in which chromosome \#17 is not involved. Although a comparative structure/function analysis of potentially relevant genes to the translocation breakpoints in both t(X;15) and t(15;17) APL showed no major alterations, the enhanced expression of the c-Kiras oncogene observed in t(X;15) APL supports the concept of heterogeneity in APL at the cytogenetic and molecular levels.",

author = "Arun Srivastava and Nyla Heerema and Lauer, \{Richard C.\} and Piruz Nahreini and \{Scott Boswell\}, H. and Ronald Hoffman and Antony, \{Asok C.\}",

year = "1987",

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doi = "10.1016/0165-4608(87)90031-8",

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T1 - A variant t(X;15)(p11;q22) translocation in acute promyelocytic leukemia

AU - Srivastava, Arun

AU - Heerema, Nyla

AU - Lauer, Richard C.

AU - Nahreini, Piruz

AU - Scott Boswell, H.

AU - Hoffman, Ronald

AU - Antony, Asok C.

PY - 1987/11

Y1 - 1987/11

N2 - Nonrandom reciprocal translocations involving chromosomes #15 and #17 are characteristic anomalies in a great majority of cases of acute promyelocytic leukemia (APL). Other complex translocations in APL that invariably involve chromosome #17 also have been described. We describe a patient with clinical and morphologic characteristics of APL but with a previously undescribed acquired karyotype, t(X;15)(p11;q22). This is the first translocation in APL described in which chromosome #17 is not involved. Although a comparative structure/function analysis of potentially relevant genes to the translocation breakpoints in both t(X;15) and t(15;17) APL showed no major alterations, the enhanced expression of the c-Kiras oncogene observed in t(X;15) APL supports the concept of heterogeneity in APL at the cytogenetic and molecular levels.

AB - Nonrandom reciprocal translocations involving chromosomes #15 and #17 are characteristic anomalies in a great majority of cases of acute promyelocytic leukemia (APL). Other complex translocations in APL that invariably involve chromosome #17 also have been described. We describe a patient with clinical and morphologic characteristics of APL but with a previously undescribed acquired karyotype, t(X;15)(p11;q22). This is the first translocation in APL described in which chromosome #17 is not involved. Although a comparative structure/function analysis of potentially relevant genes to the translocation breakpoints in both t(X;15) and t(15;17) APL showed no major alterations, the enhanced expression of the c-Kiras oncogene observed in t(X;15) APL supports the concept of heterogeneity in APL at the cytogenetic and molecular levels.

UR - https://www.scopus.com/pages/publications/0023261232

U2 - 10.1016/0165-4608(87)90031-8

DO - 10.1016/0165-4608(87)90031-8

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AN - SCOPUS:0023261232

SN - 0165-4608

VL - 29

SP - 65

EP - 74

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

A variant t(X;15)(p11;q22) translocation in acute promyelocytic leukemia

Abstract

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