TY - JOUR
T1 - A transdisciplinary team approach to scoping reviews
T2 - The case of pediatric polypharmacy
AU - Bakaki, Paul M.
AU - Staley, Jennifer
AU - Liu, Rujia
AU - Dawson, Neal
AU - Golchin, Negar
AU - Horace, Alexis
AU - Johnson, Hannah
AU - Waldron, Jennifer
AU - Winterstein, Almut
AU - Kleinman, Lawrence C.
AU - Bolen, Shari D.
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/10/4
Y1 - 2018/10/4
N2 - Background: Polypharmacy can be either beneficial or harmful to children. We conducted a scoping review to examine the concept of pediatric polypharmacy: its definition, prevalence, extent and gaps in research. In this manuscript, we report our transdisciplinary scoping review methodology. Methods: After establishing a transdisciplinary team, we iteratively developed standard operating procedures for the study's search strategy, inclusion/exclusion criteria, screening, and data extraction. We searched eight bibliographic databases, screened abstracts and full text articles, and extracted data from included studies using standardized forms. We held regular team meetings and performed ongoing internal validity measurements to maintain consistent and quality outputs. Results: With the aid of EPPI Reviewer collaborative software, our transdisciplinary team of nine members performed dual reviews of 363 included studies after dual screening of 4398 abstracts and 1082 full text articles. We achieved overall agreement of 85% and a kappa coefficient of 0.71 (95% CI 0.68-0.74) while screening full text articles. The screening and review processes required about seven hours per extracted study. The two pharmacists, an epidemiologist, a neurologist, and a librarian on the review team provided internal consultation in these key disciplines. A stakeholder group of 10 members with expertise in evidence synthesis, research implementation, pediatrics, mental health, epilepsy, pharmacoepidemiology, and pharmaceutical outcomes were periodically consulted to further characterize pediatric polypharmacy. Conclusions: A transdisciplinary approach to scoping reviews, including internal and external consultation, should be considered when addressing complex cross-disciplinary questions.
AB - Background: Polypharmacy can be either beneficial or harmful to children. We conducted a scoping review to examine the concept of pediatric polypharmacy: its definition, prevalence, extent and gaps in research. In this manuscript, we report our transdisciplinary scoping review methodology. Methods: After establishing a transdisciplinary team, we iteratively developed standard operating procedures for the study's search strategy, inclusion/exclusion criteria, screening, and data extraction. We searched eight bibliographic databases, screened abstracts and full text articles, and extracted data from included studies using standardized forms. We held regular team meetings and performed ongoing internal validity measurements to maintain consistent and quality outputs. Results: With the aid of EPPI Reviewer collaborative software, our transdisciplinary team of nine members performed dual reviews of 363 included studies after dual screening of 4398 abstracts and 1082 full text articles. We achieved overall agreement of 85% and a kappa coefficient of 0.71 (95% CI 0.68-0.74) while screening full text articles. The screening and review processes required about seven hours per extracted study. The two pharmacists, an epidemiologist, a neurologist, and a librarian on the review team provided internal consultation in these key disciplines. A stakeholder group of 10 members with expertise in evidence synthesis, research implementation, pediatrics, mental health, epilepsy, pharmacoepidemiology, and pharmaceutical outcomes were periodically consulted to further characterize pediatric polypharmacy. Conclusions: A transdisciplinary approach to scoping reviews, including internal and external consultation, should be considered when addressing complex cross-disciplinary questions.
KW - Collaborative research
KW - Pediatric polypharmacy
KW - Scoping review
KW - Team science
KW - Transdisciplinary research
UR - http://www.scopus.com/inward/record.url?scp=85054435296&partnerID=8YFLogxK
U2 - 10.1186/s12874-018-0560-4
DO - 10.1186/s12874-018-0560-4
M3 - Article
C2 - 30286720
AN - SCOPUS:85054435296
SN - 1471-2288
VL - 18
JO - BMC Medical Research Methodology
JF - BMC Medical Research Methodology
IS - 1
M1 - 102
ER -