@article{7a70dee8e54b4cc38838e957c1d83777,
title = "A tipping point in cancer epidemiology: embracing a life course exposomic framework",
abstract = "The pathogenesis of multifactorial malignant diseases, with variable onset, severity, and natural history, reflects development-specific exposures and individual responses to these exposures influenced by underlying genetic predisposition. Embedded in life course theory, exposomics provides a framework to more fully elucidate how environmental factors alter cancer risk, disease course, and response to treatment across the lifespan.",
keywords = "air pollution, carcinogens, exposome, life course theory, pediatric cancer, radon",
author = "Wright, {Rosalind J.} and Hanson, {Heidi A.}",
note = "Funding Information: During preparation of this manuscript R.J.W. was supported by UH3OD023337, P30ES023515, and UL1TR001433; H.A.H. was supported by the Joint Design of Advanced Computing Solutions for Cancer (JDACS4C) and the National Cancer Institute (NCI) of the National Institutes of Health DE-AC05-00OR22725. This work was authored, in part, by UT-Battelle, LLC under Contract No. DE-AC05-00OR22725 with the US Department of Energy. The US Government retains a non-exclusive, paid-up, irrevocable, world-wide license to publish or reproduce the published form of this manuscript, or allow others to do so, for US Government purposes. None declared by authors. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",
year = "2022",
month = apr,
doi = "10.1016/j.trecan.2022.01.016",
language = "English",
volume = "8",
pages = "280--282",
journal = "Trends in Cancer",
issn = "2405-8033",
publisher = "Cell Press",
number = "4",
}