A Thousand and One Receptor Tyrosine Kinases: Wherein the Specificity?

Harish N. Vasudevan, Philippe Soriano

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

12 Scopus citations

Abstract

Over 20 years ago, a series of seminal studies in PC12 neurons provided a framework for how receptor tyrosine kinases generate many different outcomes despite activating a set of shared intracellular pathways. In this essay, we revisit the question of receptor tyrosine kinase specificity. We first examine the relationship between receptor phosphorylation and intracellular pathway activation. We then consider the mechanisms through which signaling dynamics encode distinct cellular outcomes and finally discuss how two different receptors drive divergent transcriptional responses within the same developmental context. Establishing the key parameters that dictate the response to growth factor stimulation is critical for determining how receptor tyrosine kinases orchestrate development, an essential prerequisite for understanding the pathological consequences when such signaling processes go awry.

Original languageEnglish
Title of host publicationCurrent Topics in Developmental Biology
PublisherAcademic Press Inc.
Pages393-404
Number of pages12
DOIs
StatePublished - 1 Dec 2016

Publication series

NameCurrent Topics in Developmental Biology
Volume117
ISSN (Print)0070-2153

Keywords

  • Cell signaling
  • Differentiation
  • ERK
  • Migration
  • PI3K
  • Proliferation

Fingerprint

Dive into the research topics of 'A Thousand and One Receptor Tyrosine Kinases: Wherein the Specificity?'. Together they form a unique fingerprint.

Cite this