A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23

Biochemistry, Genetics and Molecular Biology

• Kinesin 100%
• Cell Death 66%
• Transcription Factors 66%
• Tumor Immune Microenvironment 66%
• Genetics 33%
• Cell Proliferation 33%
• RNA Sequence 33%
• Tumor Progression 33%
• Oxidoreductase 33%
• Serotype 33%
• Reductase 33%
• Mediator 33%
• Synthase 33%
• Adeno Associated Virus 33%
• Synapsin I 33%
• Statin 33%
• Protein Ligand 33%
• Chromatin Immunoprecipitation 33%
• Long Term Survival 33%
• Cholesterol Synthesis 33%
• HMG-CoA 33%
• Guide RNA 33%
• Sterol Regulatory Element Binding Protein 2 33%
• Farnesyl-Diphosphate Farnesyltransferase 33%
• Farnesyl Pyrophosphate 33%
• Sorafenib 33%
• Cholesterol 33%
• Targeted Therapy 33%
• CRISPR 33%

Keyphrases

• Hepatocellular Carcinoma 100%
• Anillin 100%
• TEAD2 100%
• Kinesin Family Member 23 100%
• Targetable 100%
• Tumor Cells 25%
• Yes-associated Protein 1 (YAP1) 25%
• Therapeutic Target 16%
• Tumor Immune Microenvironment 16%
• CTNNB1 16%
• Geranylgeranyl Diphosphate Synthase 16%
• TEA Domain Transcription Factors 16%
• Cell Death 8%
• Cholesterol 8%
• Pharmacologic 8%
• Adenovirus 8%
• RNA Sequencing (RNA-seq) 8%
• Overexpression 8%
• Long-term Survival 8%
• Tumor Growth 8%
• Knock-in Mouse Model 8%
• Targeted Therapy 8%
• Statins 8%
• Human Hepatocellular Carcinoma 8%
• Effects on Survival 8%
• Programmed Death-ligand 1 (PD-L1) 8%
• DCas9 8%
• Sorafenib 8%
• Chromatin Immunoprecipitation (ChIP) 8%
• Tumor Cell Proliferation 8%
• Cell-intrinsic 8%
• Reductase 8%
• 3-hydroxy-3-methylglutaryl-coenzyme A 8%
• Therapeutic Targeting 8%
• Cholesterol Biosynthesis 8%
• Floxed 8%
• Carbon Tetrachloride 8%
• Transcription Inhibitors 8%
• Palindromic 8%
• Virus Serotype 8%
• Hepatocellular Carcinoma Therapy 8%
• Transcriptional Coactivator with PDZ-binding Motif 8%
• Diethylnitrosamine 8%
• SREBP2 8%
• Sleeping Beauty 8%
• CRISPR Activation 8%
• Serotype 8 8%
• TEAD4 8%
• Proliferation Cell 8%
• Guide RNA (gRNA) 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Liver Cell Carcinoma 100%
• Kinesin 100%
• Neoplasm 42%
• Transcription Factors 14%
• Cholesterol 14%
• Tumor Growth 7%
• Statin (Protein) 7%
• Long Term Survival 7%
• Carbon Tetrachloride 7%
• Synthetase 7%
• Programmed Cell Death 7%
• Protein Ligand 7%
• Sorafenib 7%
• Adeno Associated Virus 7%
• Synapsin I 7%
• Oxidoreductase 7%
• HMG-CoA 7%
• Chromatin Immunoprecipitation 7%
• Diethylnitrosamine 7%
• Guide RNA 7%
• Squalene Synthase 7%
• Sterol Regulatory Element Binding Protein 2 7%
• Farnesyl Diphosphate 7%