A therapeutic dendritic cell-based vaccine for HIV-1 infection

Felipe García; Núria Climent; Lambert Assoumou; Cristina Gil; Nuria González; José Alcamí; Agathe León; Joan Romeu; Judith Dalmau; Javier Martínez-Picado; Jeff Lifson; Brigitte Autran; Dominique Costagliola; Bonaventura Clotet; Josep M. Gatell; Montserrat Plana; Teresa Gallart

doi:10.1093/infdis/jiq077

A therapeutic dendritic cell-based vaccine for HIV-1 infection

Felipe García, Núria Climent, Lambert Assoumou, Cristina Gil, Nuria González, José Alcamí, Agathe León, Joan Romeu, Judith Dalmau, Javier Martínez-Picado, Jeff Lifson, Brigitte Autran, Dominique Costagliola, Bonaventura Clotet, Josep M. Gatell, Montserrat Plana, Teresa Gallart

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

A double-blinded, controlled study of vaccination of untreated patients with chronic human immunodeficiency virus type 1 (HIV-1) infection with 3 doses of autologous monocyte-derived dendritic cells (MD-DCs) pulsed with heat inactivated autologous HIV-1 was performed. Therapeutic vaccinations were feasible, safe, and well tolerated. At week 24 after first vaccination (primary end point), a modest significant decrease in plasma viral load was observed in vaccine recipients, compared with control subjects (P = .03). In addition, the change in plasma viral load after vaccination tended to be inversely associated with the increase in HIV-specific T cell responses in vaccinated patients but tended to be directly correlated with HIV-specific T cell responses in control subjects. Clinical trial.gov NCT00402142.

Original language	English
Pages (from-to)	473-478
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	203
Issue number	4
DOIs	https://doi.org/10.1093/infdis/jiq077
State	Published - 15 Feb 2011
Externally published	Yes

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García, F., Climent, N., Assoumou, L., Gil, C., González, N., Alcamí, J., León, A., Romeu, J., Dalmau, J., Martínez-Picado, J., Lifson, J., Autran, B., Costagliola, D., Clotet, B., Gatell, J. M., Plana, M., & Gallart, T. (2011). A therapeutic dendritic cell-based vaccine for HIV-1 infection. Journal of Infectious Diseases, 203(4), 473-478. https://doi.org/10.1093/infdis/jiq077

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title = "A therapeutic dendritic cell-based vaccine for HIV-1 infection",

abstract = "A double-blinded, controlled study of vaccination of untreated patients with chronic human immunodeficiency virus type 1 (HIV-1) infection with 3 doses of autologous monocyte-derived dendritic cells (MD-DCs) pulsed with heat inactivated autologous HIV-1 was performed. Therapeutic vaccinations were feasible, safe, and well tolerated. At week 24 after first vaccination (primary end point), a modest significant decrease in plasma viral load was observed in vaccine recipients, compared with control subjects (P = .03). In addition, the change in plasma viral load after vaccination tended to be inversely associated with the increase in HIV-specific T cell responses in vaccinated patients but tended to be directly correlated with HIV-specific T cell responses in control subjects. Clinical trial.gov NCT00402142.",

author = "Felipe Garc{\'i}a and N{\'u}ria Climent and Lambert Assoumou and Cristina Gil and Nuria Gonz{\'a}lez and Jos{\'e} Alcam{\'i} and Agathe Le{\'o}n and Joan Romeu and Judith Dalmau and Javier Mart{\'i}nez-Picado and Jeff Lifson and Brigitte Autran and Dominique Costagliola and Bonaventura Clotet and Gatell, {Josep M.} and Montserrat Plana and Teresa Gallart",

note = "Funding Information: This study was partially supported by grants: FIS PS09/01297, FIPSE 36750/08, SAF2008-04395, SAF 05/05566, FIPSE 36536/05, FIS 040503, FIS 070291, contract FIS 03/0072, Mutua Madrile{\~n}a del Autom{\'o}vil, STREP (UE) Life sciences, genomics and biotechnology for health LSH2005_2.3.0.10, PROFIT (FIT 090100-2005-9), MARAT{\'O}TV3, RIS**, ORVACS***. Funding Information: Dr Felipe Garc{\'i}a was recipient of a Research Grant from IDIBAPS****, Barcelona, Spain.",

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García, F, Climent, N, Assoumou, L, Gil, C, González, N, Alcamí, J, León, A, Romeu, J, Dalmau, J, Martínez-Picado, J, Lifson, J, Autran, B, Costagliola, D, Clotet, B, Gatell, JM, Plana, M & Gallart, T 2011, 'A therapeutic dendritic cell-based vaccine for HIV-1 infection', Journal of Infectious Diseases, vol. 203, no. 4, pp. 473-478. https://doi.org/10.1093/infdis/jiq077

TY - JOUR

T1 - A therapeutic dendritic cell-based vaccine for HIV-1 infection

AU - García, Felipe

AU - Climent, Núria

AU - Assoumou, Lambert

AU - Gil, Cristina

AU - González, Nuria

AU - Alcamí, José

AU - León, Agathe

AU - Romeu, Joan

AU - Dalmau, Judith

AU - Martínez-Picado, Javier

AU - Lifson, Jeff

AU - Autran, Brigitte

AU - Costagliola, Dominique

AU - Clotet, Bonaventura

AU - Gatell, Josep M.

AU - Plana, Montserrat

AU - Gallart, Teresa

N1 - Funding Information: This study was partially supported by grants: FIS PS09/01297, FIPSE 36750/08, SAF2008-04395, SAF 05/05566, FIPSE 36536/05, FIS 040503, FIS 070291, contract FIS 03/0072, Mutua Madrileña del Automóvil, STREP (UE) Life sciences, genomics and biotechnology for health LSH2005_2.3.0.10, PROFIT (FIT 090100-2005-9), MARATÓTV3, RIS**, ORVACS***. Funding Information: Dr Felipe García was recipient of a Research Grant from IDIBAPS****, Barcelona, Spain.

PY - 2011/2/15

Y1 - 2011/2/15

N2 - A double-blinded, controlled study of vaccination of untreated patients with chronic human immunodeficiency virus type 1 (HIV-1) infection with 3 doses of autologous monocyte-derived dendritic cells (MD-DCs) pulsed with heat inactivated autologous HIV-1 was performed. Therapeutic vaccinations were feasible, safe, and well tolerated. At week 24 after first vaccination (primary end point), a modest significant decrease in plasma viral load was observed in vaccine recipients, compared with control subjects (P = .03). In addition, the change in plasma viral load after vaccination tended to be inversely associated with the increase in HIV-specific T cell responses in vaccinated patients but tended to be directly correlated with HIV-specific T cell responses in control subjects. Clinical trial.gov NCT00402142.

AB - A double-blinded, controlled study of vaccination of untreated patients with chronic human immunodeficiency virus type 1 (HIV-1) infection with 3 doses of autologous monocyte-derived dendritic cells (MD-DCs) pulsed with heat inactivated autologous HIV-1 was performed. Therapeutic vaccinations were feasible, safe, and well tolerated. At week 24 after first vaccination (primary end point), a modest significant decrease in plasma viral load was observed in vaccine recipients, compared with control subjects (P = .03). In addition, the change in plasma viral load after vaccination tended to be inversely associated with the increase in HIV-specific T cell responses in vaccinated patients but tended to be directly correlated with HIV-specific T cell responses in control subjects. Clinical trial.gov NCT00402142.

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DO - 10.1093/infdis/jiq077

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AN - SCOPUS:79751500441

SN - 0022-1899

VL - 203

SP - 473

EP - 478

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 4

ER -

A therapeutic dendritic cell-based vaccine for HIV-1 infection

Abstract

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