A targeted, image-guided and dually locked photoresponsive drug delivery system

S. Karthik; B. N. Prashanth Kumar; Moumita Gangopadhyay; Mahitosh Mandal; N. D.Pradeep Singh

doi:10.1039/c4tb01583e

A targeted, image-guided and dually locked photoresponsive drug delivery system

S. Karthik
, B. N. Prashanth Kumar
, Moumita Gangopadhyay
, Mahitosh Mandal
, N. D.Pradeep Singh

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

We have developed a new targeted image-guided photoresponsive drug delivery system (DDS) based on a dual locking strategy. Excitation of the DDS by fluorescent light results in the first unlocking and activation of the drug, and allows real-time monitoring of the prodrug. Extended irradiation results in a second unlocking, giving drug release within cancer cells.

Original language	English
Pages (from-to)	728-732
Number of pages	5
Journal	Journal of Materials Chemistry B
Volume	3
Issue number	5
DOIs	https://doi.org/10.1039/c4tb01583e
State	Published - 7 Feb 2015
Externally published	Yes

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title = "A targeted, image-guided and dually locked photoresponsive drug delivery system",

abstract = "We have developed a new targeted image-guided photoresponsive drug delivery system (DDS) based on a dual locking strategy. Excitation of the DDS by fluorescent light results in the first unlocking and activation of the drug, and allows real-time monitoring of the prodrug. Extended irradiation results in a second unlocking, giving drug release within cancer cells.",

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AU - Karthik, S.

AU - Prashanth Kumar, B. N.

AU - Gangopadhyay, Moumita

AU - Mandal, Mahitosh

AU - Singh, N. D.Pradeep

PY - 2015/2/7

Y1 - 2015/2/7

N2 - We have developed a new targeted image-guided photoresponsive drug delivery system (DDS) based on a dual locking strategy. Excitation of the DDS by fluorescent light results in the first unlocking and activation of the drug, and allows real-time monitoring of the prodrug. Extended irradiation results in a second unlocking, giving drug release within cancer cells.

AB - We have developed a new targeted image-guided photoresponsive drug delivery system (DDS) based on a dual locking strategy. Excitation of the DDS by fluorescent light results in the first unlocking and activation of the drug, and allows real-time monitoring of the prodrug. Extended irradiation results in a second unlocking, giving drug release within cancer cells.

UR - https://www.scopus.com/pages/publications/84921654243

U2 - 10.1039/c4tb01583e

DO - 10.1039/c4tb01583e

M3 - Article

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SP - 728

EP - 732

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 5

ER -

A targeted, image-guided and dually locked photoresponsive drug delivery system

Abstract

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