A Tale of Two Genes: Microglial Apoe and Trem2

Anna A. Pimenova; Edoardo Marcora; Alison M. Goate

doi:10.1016/j.immuni.2017.08.015

A Tale of Two Genes: Microglial Apoe and Trem2

Anna A. Pimenova, Edoardo Marcora, Alison M. Goate

Research output: Contribution to journal › Short survey › peer-review

38 Scopus citations

Abstract

Microglial cell function is implicated in the etiology of Alzheimer's disease by human genetics. In this issue of Immunity, Krasemann et al. (2017) describe a gene expression signature associated with an APOE- and TREM2-dependent response of microglia to brain tissue damage that accumulates in aging and disease, defining an axis that might be amenable to therapeutic targeting. Microglial cell function is implicated in the etiology of Alzheimer's disease by human genetics. In this issue of Immunity, Krasemann et al. (2017) describe a gene expression signature associated with an ApoE- and Trem2-dependent response of microglia to brain tissue damage that accumulates in aging and disease, defining an axis that might be amenable to therapeutic targeting.

Original language	English
Pages (from-to)	398-400
Number of pages	3
Journal	Immunity
Volume	47
Issue number	3
DOIs	https://doi.org/10.1016/j.immuni.2017.08.015
State	Published - 19 Sep 2017

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title = "A Tale of Two Genes: Microglial Apoe and Trem2",

abstract = "Microglial cell function is implicated in the etiology of Alzheimer's disease by human genetics. In this issue of Immunity, Krasemann et al. (2017) describe a gene expression signature associated with an APOE- and TREM2-dependent response of microglia to brain tissue damage that accumulates in aging and disease, defining an axis that might be amenable to therapeutic targeting. Microglial cell function is implicated in the etiology of Alzheimer's disease by human genetics. In this issue of Immunity, Krasemann et al. (2017) describe a gene expression signature associated with an ApoE- and Trem2-dependent response of microglia to brain tissue damage that accumulates in aging and disease, defining an axis that might be amenable to therapeutic targeting.",

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A Tale of Two Genes: Microglial Apoe and Trem2

Abstract

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