TY - JOUR
T1 - A Systematic Review and Meta-Analysis of the Prevalence of Triplex Infections (Combined Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus) among Pregnant Women in Nigeria
AU - Eleje, George Uchenna
AU - Loto, Olabisi Morebise
AU - Usman, Hadiza Abdullahi
AU - Onubogu, Chinyere Ukamaka
AU - Fiebai, Preye Owen
AU - Akaba, Godwin Otuodichinma
AU - Rabiu, Ayyuba
AU - Mbachu, Ikechukwu Innocent
AU - Chibuzor, Moriam Taiwo
AU - Chukwuanukwu, Rebecca Chinyelu
AU - Joe-Ikechebelu, Ngozi Nneka
AU - Igbodike, Emeka Philip
AU - Egeonu, Richard Obinwanne
AU - Oppah, Ijeoma Chioma
AU - Ogwaluonye, Uchenna Chukwunonso
AU - Nwankwo, Chike Henry
AU - Kalu, Stephen Okoroafor
AU - Chigbo, Chisom God Swill
AU - Ogbuagu, Chukwuanugo Nkemakonam
AU - Chukwurah, Shirley Nneka
AU - Uzochukwu, Chinwe Elizabeth
AU - Ahmed, Aishat
AU - Jibuaku, Chiamaka Henrietta
AU - Inuyomi, Samuel Oluwagbenga
AU - Adesoji, Bukola Abimbola
AU - Anyang, Ubong Inyang
AU - Emeka, Ekene Agatha
AU - Igue, Odion Emmanuel
AU - Okoro, Ogbonna Dennis
AU - Aja, Prince Ogbonnia
AU - Chidozie, Chiamaka Perpetua
AU - Ibrahim, Hadiza Sani
AU - Aliyu, Fatima Ele
AU - Ugwuoroko, Harrison Chiro
AU - Numan, Aisha Ismaila
AU - Omoruyi, Solace Amechi
AU - Umeononihu, Osita Samuel
AU - Okoro, Chukwuemeka Chukwubuikem
AU - Nwaeju, Ifeanyi Kingsley
AU - Onwuegbuna, Arinze Anthony
AU - Eleje, Lydia Ijeoma
AU - Ikwuka, David Chibuike
AU - Umeh, Eric Okechukwu
AU - Nweje, Sussan Ifeyinwa
AU - Ajuba, Ifeoma Clara
AU - Ugwu, Angela Ogechukwu
AU - Ebubedike, Uzoamaka Rufina
AU - Malachy, Divinefavour Echezona
AU - Okafor, Chigozie Geoffrey
AU - Obiegbu, Nnaedozie Paul
AU - Ugwu, Emmanuel Onyebuchi
AU - Yakasai, Ibrahim Adamu
AU - Ezechi, Oliver Chukwujekwu
AU - Ikechebelu, Joseph Ifeanyichukwu
N1 - Publisher Copyright:
© 2023 George Uchenna Eleje et al.
PY - 2023
Y1 - 2023
N2 - Objective. We systematically identified the prevalence of triplex infections (combined human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV)) in pregnancy. Methods. To gather information on the frequency of triplex infections, we searched the databases of PubMed, CINAHL, and Google Scholar. Without regard to language, we utilized search terms that covered HIV, HBV, HCV, and pregnancy. Pregnant women with triplex infections of HIV, HBV, and HCV were included in studies that also examined the prevalence of triplex infections. Review Manager 5.4.1 was employed to conduct the meta-analysis. Critical appraisal and bias tool risk data were provided as percentages with 95% confidence intervals (95% CIs), and I2 was used as the statistical measure of heterogeneity. The checklist was created by Hoy and colleagues. The study protocol was registered on PROSPERO, under the registration number CRD42020202583. Results. Eight studies involving 5314 women were included. We identified one ongoing study. Pooled prevalence of triplex infections was 0.03% (95% CI: 0.02-0.04%) according to meta-analysis. Subgroup analysis demonstrated a significantly high prevalence of 0.08% (95% CI: 0.06-0.10%; 3863 women) in HIV-positive population than 0.00% (95% CI:-0.00-0.00; 1451 women; P<0.001) in general obstetric population. Moreover, there was a significant difference in the pooled prevalence between studies published between 2001 and 2010 and between 2011 and 2021 (0.14% (95% CI: 0.12 to 0.16 versus 0.03% (95% CI: 0.02 to 0.04%; P<0.001))) and participants recruited in the period between 2001 and 2011 and between 2012 and 2021 (0.13% (95% CI: 0.05 to 0.21; p=0.002 versus 0.00% (95% CI: -0.00 to 0.00%; p=1.00))), respectively. Conclusion. The combined prevalence of prenatal triplex infections was 0.03%, with rates notably higher among the group of pregnant women who were HIV-positive and during the recruitment period that took place before 2012. This prevalence still necessitates screening for these infections as necessary.
AB - Objective. We systematically identified the prevalence of triplex infections (combined human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV)) in pregnancy. Methods. To gather information on the frequency of triplex infections, we searched the databases of PubMed, CINAHL, and Google Scholar. Without regard to language, we utilized search terms that covered HIV, HBV, HCV, and pregnancy. Pregnant women with triplex infections of HIV, HBV, and HCV were included in studies that also examined the prevalence of triplex infections. Review Manager 5.4.1 was employed to conduct the meta-analysis. Critical appraisal and bias tool risk data were provided as percentages with 95% confidence intervals (95% CIs), and I2 was used as the statistical measure of heterogeneity. The checklist was created by Hoy and colleagues. The study protocol was registered on PROSPERO, under the registration number CRD42020202583. Results. Eight studies involving 5314 women were included. We identified one ongoing study. Pooled prevalence of triplex infections was 0.03% (95% CI: 0.02-0.04%) according to meta-analysis. Subgroup analysis demonstrated a significantly high prevalence of 0.08% (95% CI: 0.06-0.10%; 3863 women) in HIV-positive population than 0.00% (95% CI:-0.00-0.00; 1451 women; P<0.001) in general obstetric population. Moreover, there was a significant difference in the pooled prevalence between studies published between 2001 and 2010 and between 2011 and 2021 (0.14% (95% CI: 0.12 to 0.16 versus 0.03% (95% CI: 0.02 to 0.04%; P<0.001))) and participants recruited in the period between 2001 and 2011 and between 2012 and 2021 (0.13% (95% CI: 0.05 to 0.21; p=0.002 versus 0.00% (95% CI: -0.00 to 0.00%; p=1.00))), respectively. Conclusion. The combined prevalence of prenatal triplex infections was 0.03%, with rates notably higher among the group of pregnant women who were HIV-positive and during the recruitment period that took place before 2012. This prevalence still necessitates screening for these infections as necessary.
UR - https://www.scopus.com/pages/publications/85168757205
U2 - 10.1155/2023/3551297
DO - 10.1155/2023/3551297
M3 - Review article
AN - SCOPUS:85168757205
SN - 1687-9589
VL - 2023
JO - Obstetrics and Gynecology International
JF - Obstetrics and Gynecology International
M1 - 3551297
ER -