Abstract
We studied the effects of lorazepam and dextromethorphan on the responses to 1 Hz repetitive transcranial magnetic stimulation applied to the left human motor cortex. Lorazepam, dextromethorphan or placebo was administered to 45 normal controls in a double-blind fashion 2.5 h before the repetitive transcranial magnetic stimulation procedure. Motor cortical excitability was measured with single transcranial magnetic stimulation pulses before and after 15 min of 1 Hz repetitive transcranial magnetic stimulation applied at supra-threshold intensity. 1 Hz repetitive transcranial magnetic stimulation resulted in a decrease in motor cortical excitability in the placebo group but not in the groups taking lorazepam or dextromethorphan. These results suggest that cortical responses to 1 Hz repetitive transcranial magnetic stimulation are dependent on activity at both γ-aminobutyric acid and N-methyl-D-asparate receptor systems. NeuroReport 16:1525-1528.
| Original language | English |
|---|---|
| Pages (from-to) | 1525-1528 |
| Number of pages | 4 |
| Journal | NeuroReport |
| Volume | 16 |
| Issue number | 13 |
| DOIs | |
| State | Published - 8 Sep 2005 |
| Externally published | Yes |
Keywords
- Cortical inhibition
- Dextromethorphan
- Lorazepam
- Plasticity
- Repetitive transcranial magnetic stimulation
Fingerprint
Dive into the research topics of 'A study of the effects of lorazepam and dextromethorphan on the response to cortical 1 Hz repetitive transcranial magnetic stimulation'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver