Abstract
The production of cortisol and aldosterone by the adrenal cortex involves a succession of 'enzyme systems'. This study presents an integrated quantitative view of these successive biosynthetic steps and their importance in clinical disorders related to an excess or deficiency of these hormones. A numerical digital computer model has been used to study the modulation of the biosynthesis and secretion of these hormones under physiological and certain pathological conditions. Biochemically based hypotheses for the structure of the adrenocortical system and enzymatic rate equations, including the effects of inhibition, stimulation, and feedback regulations form the basis of it.
| Original language | English |
|---|---|
| Pages (from-to) | S2-S39 |
| Journal | Mount Sinai Journal of Medicine |
| Volume | 42 |
| Issue number | 6 |
| State | Published - 1975 |
| Externally published | Yes |