A stem cell molecutar signature

Natalia B. Ivanova; John T. Dimos; Christoph Schaniel; Jason A. Hackney; Kateri A. Moore; Ihor R. Lemischka

doi:10.1126/science.1073823

A stem cell molecutar signature

Natalia B. Ivanova, John T. Dimos, Christoph Schaniel, Jason A. Hackney, Kateri A. Moore, Ihor R. Lemischka

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1251 Scopus citations

Abstract

Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.

Original language	English
Pages (from-to)	601-604
Number of pages	4
Journal	Science
Volume	298
Issue number	5593
DOIs	https://doi.org/10.1126/science.1073823
State	Published - 18 Oct 2002
Externally published	Yes

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abstract = "Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.",

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AU - Dimos, John T.

AU - Schaniel, Christoph

AU - Hackney, Jason A.

AU - Moore, Kateri A.

AU - Lemischka, Ihor R.

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AB - Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.

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A stem cell molecutar signature

Abstract

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