@article{18f5c955b31e4cb1ab1381c5a6b58338,
title = "A specific requirement for PDGF-C in palate formation and PDGFR-α signaling",
abstract = "PDGF-C is a member of the platelet-derived growth factor (PDGF) family, which signals through PDGF receptor (PDGFR) αα and αβ dimers. Here we show that Pdgfc-/- mice die in the perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate. This phenotype was less severe than that of Pdgfra -/- embryos. Pdgfc-/- Pdgfa-/- embryos developed a cleft face, subepidermal blistering, deficiency of renal cortex mesenchyme, spina bifida and skeletal and vascular defects. Complete loss of function of both ligands, therefore, phenocopied the loss of PDGFR-α function, suggesting that both PDGF-A and PDGF-C signal through PDGFR-α to regulate the development of craniofacial structures, the neural tube and mesodermal organs. Our results also show that PDGF-C signaling is a new pathway in palatogenesis, different from, and independent of, those previously implicated.",
author = "Hao Ding and Xiaoli Wu and Hans Bostr{\"o}m and Injune Kim and Nicole Wong and Bonny Tsoi and Meredith O'Rourke and Koh, \{Gou Young\} and Philippe Soriano and Christer Betsholtz and Hart, \{Thomas C.\} and Marazita, \{Mary L.\} and Field, \{L. L.\} and Tam, \{Patrick P.L.\} and Andras Nagy",
note = "Funding Information: We thank P. Rowe and J. Rossant for reading the manuscript. This work was supported by grants from the National Cancer Institute of Canada Terry Fox Foundation (A.N.); the National Health and Medical Research Council of Australia (P.P.L.T.); and the National Institutes of Health, National Institute of Dental and Craniofacial Research (M.L.M. and L.L.F.). H.D. was supported by a fellowship from the Canadian Institute of Health Research and a developmental grant from the American Muscular Dystrophy Association. H.D. holds a Canada Research Chair. P.P.L.T. is a National Health and Medical Research Council Senior Principal Research Fellow and A.N. is a Senior Scientist of the Canadian Institute of Health Research.",
year = "2004",
month = oct,
doi = "10.1038/ng1415",
language = "English",
volume = "36",
pages = "1111--1116",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Research",
number = "10",
}