TY - GEN
T1 - A simulation model of the counting-rate response of clinical pet systems and it's application to optimize the injected dose
AU - Karakatsanis, Nicolas
AU - Nikita, Konstantina
PY - 2009
Y1 - 2009
N2 - The design principles of clinical PET data acquisition protocols require images of high statistical quality, while the scanning time remains relatively short and the total amount of radioactive dose does not exceed a level, above which significant count losses are observed. This can be satisfied by determining a range of injected dose levels where the performance parameter of Noise Equivalent Count Rate (NECR) is maximized. However certain patient- and scanner-related parameters can shift the range. We propose a methodology to design a model of the NECR response to certain patient-scanner parameters, based on validated simulations of imaging systems and realistic human phantoms. We used Geant4 Application for Tomography Emission and investigated the relationship between the NECR and the patient size, the coincidence time window of the scanner, the dead-time of the system's electronics and the energy window.
AB - The design principles of clinical PET data acquisition protocols require images of high statistical quality, while the scanning time remains relatively short and the total amount of radioactive dose does not exceed a level, above which significant count losses are observed. This can be satisfied by determining a range of injected dose levels where the performance parameter of Noise Equivalent Count Rate (NECR) is maximized. However certain patient- and scanner-related parameters can shift the range. We propose a methodology to design a model of the NECR response to certain patient-scanner parameters, based on validated simulations of imaging systems and realistic human phantoms. We used Geant4 Application for Tomography Emission and investigated the relationship between the NECR and the patient size, the coincidence time window of the scanner, the dead-time of the system's electronics and the energy window.
KW - Biomedical imaging
KW - Dose
KW - Monte carlo methods
KW - Optimization methods
KW - Positron emission tomography
KW - Simulation
UR - http://www.scopus.com/inward/record.url?scp=70449368559&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2009.5193068
DO - 10.1109/ISBI.2009.5193068
M3 - Conference contribution
AN - SCOPUS:70449368559
SN - 9781424439324
T3 - Proceedings - 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009
SP - 398
EP - 401
BT - Proceedings - 2009 IEEE International Symposium on Biomedical Imaging
T2 - 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009
Y2 - 28 June 2009 through 1 July 2009
ER -