A simple, rapid method for the preparation of [11C]formaldehyde

Jacob M. Hooker; Matthias Schönberger; Hanno Schieferstein; Joanna S. Fowler

doi:10.1002/anie.200800991

A simple, rapid method for the preparation of [¹¹C]formaldehyde

Jacob M. Hooker, Matthias Schönberger, Hanno Schieferstein, Joanna S. Fowler

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

A PET project: A powerful reagent for the synthesis of positron-emitting imaging molecules - [¹¹C]formaldehyde - is accessible from [ ¹¹C]methyl iodide and trimethylamine N-oxide (TMAO) in high yields and under mild conditions. Easy access to [¹¹C]formaldehyde expands the scope of the carbon-11 toolbox and will lead to new reaction methodology and imaging compounds. (Chemical Equation Presented).

Original language	English
Pages (from-to)	5989-5992
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	32
DOIs	https://doi.org/10.1002/anie.200800991
State	Published - 28 Jul 2008

Keywords

Formaldehyde
Isotopic labeling
N-oxides
Oxidation
Positron emission tomography

Access to Document

10.1002/anie.200800991

Cite this

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