Despite numerous animal studies indicating an important role of serotonin (5‐HT) in anxiety, 5‐HT's function in the regulation of human anxiety has hardly been studied. Recent clinical studies suggest an involvement of 5‐HT systems in panic disorder. This paper will briefly review the pertinent data on 5‐HT and panic disorder and propose a specific hypothesis on 5‐HT abnormalities in that disorder.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalHuman Psychopharmacology
Issue number4
StatePublished - Dec 1988


  • Panic disorder
  • anxiety
  • serotonin


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