TY - JOUR
T1 - A serological assay to detect SARS-CoV-2 seroconversion in humans
AU - Amanat, Fatima
AU - Stadlbauer, Daniel
AU - Strohmeier, Shirin
AU - Nguyen, Thi H.O.
AU - Chromikova, Veronika
AU - McMahon, Meagan
AU - Jiang, Kaijun
AU - Arunkumar, Guha Asthagiri
AU - Jurczyszak, Denise
AU - Polanco, Jose
AU - Bermudez-Gonzalez, Maria
AU - Kleiner, Giulio
AU - Aydillo, Teresa
AU - Miorin, Lisa
AU - Fierer, Daniel S.
AU - Lugo, Luz Amarilis
AU - Kojic, Erna Milunka
AU - Stoever, Jonathan
AU - Liu, Sean T.H.
AU - Cunningham-Rundles, Charlotte
AU - Felgner, Philip L.
AU - Moran, Thomas
AU - García-Sastre, Adolfo
AU - Caplivski, Daniel
AU - Cheng, Allen C.
AU - Kedzierska, Katherine
AU - Vapalahti, Olli
AU - Hepojoki, Jussi M.
AU - Simon, Viviana
AU - Krammer, Florian
N1 - Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Here, we describe a serological enzyme-linked immunosorbent assay for the screening and identification of human SARS-CoV-2 seroconverters. This assay does not require the handling of infectious virus, can be adjusted to detect different antibody types in serum and plasma and is amenable to scaling. Serological assays are of critical importance to help define previous exposure to SARS-CoV-2 in populations, identify highly reactive human donors for convalescent plasma therapy and investigate correlates of protection.
AB - Here, we describe a serological enzyme-linked immunosorbent assay for the screening and identification of human SARS-CoV-2 seroconverters. This assay does not require the handling of infectious virus, can be adjusted to detect different antibody types in serum and plasma and is amenable to scaling. Serological assays are of critical importance to help define previous exposure to SARS-CoV-2 in populations, identify highly reactive human donors for convalescent plasma therapy and investigate correlates of protection.
UR - http://www.scopus.com/inward/record.url?scp=85084429680&partnerID=8YFLogxK
U2 - 10.1038/s41591-020-0913-5
DO - 10.1038/s41591-020-0913-5
M3 - Article
C2 - 32398876
AN - SCOPUS:85084429680
SN - 1078-8956
VL - 26
SP - 1033
EP - 1036
JO - Nature Medicine
JF - Nature Medicine
IS - 7
ER -