A role of RGS proteins in drug addiction

Shelley B. Hooks; Kirill Martemyanov; Venetia Zachariou

doi:10.1016/j.bcp.2007.07.045

A role of RGS proteins in drug addiction

Shelley B. Hooks
, Kirill Martemyanov
, Venetia Zachariou

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

The diverse family of Regulators of G protein signaling (RGS) proteins are widely distributed proteins with multiple functions, including GAP activity for heterotrimeric G protein alpha subunits. Three members of the RGS family, RGS9-2, RGS4 and RGSz, have been shown to play an essential modulatory role in psychostimulant and opiate drug actions. Interestingly, these proteins show distinct structure, distribution pattern and cellular localization. In addition, each of these proteins is differentially regulated by drugs of abuse in particular brain networks and appears to modulate distinct signal transduction events. The striatal enriched RGS9 plays a prominent role in opiate and psychostimulant drug reward; RGS4 appears to modulate opiate dependence via actions in the locus coeruleus, whereas RGSz modulates analgesia via activation of the PKC pathway.

Original language	English
Pages (from-to)	76-84
Number of pages	9
Journal	Biochemical Pharmacology
Volume	75
Issue number	1
DOIs	https://doi.org/10.1016/j.bcp.2007.07.045
State	Published - 1 Jan 2008
Externally published	Yes

Keywords

Dopamine receptors
G protein coupled receptors
Opiate receptors
Receptor desensitization
Scaffolding protein
Signal transduction

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10.1016/j.bcp.2007.07.045

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title = "A role of RGS proteins in drug addiction",

abstract = "The diverse family of Regulators of G protein signaling (RGS) proteins are widely distributed proteins with multiple functions, including GAP activity for heterotrimeric G protein alpha subunits. Three members of the RGS family, RGS9-2, RGS4 and RGSz, have been shown to play an essential modulatory role in psychostimulant and opiate drug actions. Interestingly, these proteins show distinct structure, distribution pattern and cellular localization. In addition, each of these proteins is differentially regulated by drugs of abuse in particular brain networks and appears to modulate distinct signal transduction events. The striatal enriched RGS9 plays a prominent role in opiate and psychostimulant drug reward; RGS4 appears to modulate opiate dependence via actions in the locus coeruleus, whereas RGSz modulates analgesia via activation of the PKC pathway.",

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T1 - A role of RGS proteins in drug addiction

AU - Hooks, Shelley B.

AU - Martemyanov, Kirill

AU - Zachariou, Venetia

PY - 2008/1/1

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AB - The diverse family of Regulators of G protein signaling (RGS) proteins are widely distributed proteins with multiple functions, including GAP activity for heterotrimeric G protein alpha subunits. Three members of the RGS family, RGS9-2, RGS4 and RGSz, have been shown to play an essential modulatory role in psychostimulant and opiate drug actions. Interestingly, these proteins show distinct structure, distribution pattern and cellular localization. In addition, each of these proteins is differentially regulated by drugs of abuse in particular brain networks and appears to modulate distinct signal transduction events. The striatal enriched RGS9 plays a prominent role in opiate and psychostimulant drug reward; RGS4 appears to modulate opiate dependence via actions in the locus coeruleus, whereas RGSz modulates analgesia via activation of the PKC pathway.

KW - Dopamine receptors

KW - G protein coupled receptors

KW - Opiate receptors

KW - Receptor desensitization

KW - Scaffolding protein

KW - Signal transduction

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A role of RGS proteins in drug addiction

Abstract

Keywords

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