A Review of the Clinical Presentation, Outcomes, and Treatments of Patients Having Desmoid Tumors

Carlos Figueredo, Thomas Schiano

Research output: Contribution to journalReview articlepeer-review

Abstract

Desmoid tumors (DTs) are deep fibroblastic neoplasms that arise from musculo-aponeurotic stromal elements. DTs may result in significant morbidity by infiltrating vital anatomic structures. Their mortality is often due to the local aggressiveness, most commonly when intra-abdominal in location. Some indolent DTs can be observed expectantly; infiltrative tumors require an aggressive and multidisciplinary approach and are offered conservative therapies such as nonsteroidal anti-inflammatory drugs or antiestrogens when surgery is not feasible. Comparably, chemotherapy is considered for those cases not amenable to surgery or radiation. Bowel resection and at times intestinal transplantation may be necessary. However, DTs may recur postsurgery making long-term management of these patients. Herein, we review the genetics, clinical presentations, outcomes, and treatments of DTs.

Original languageEnglish
Pages (from-to)588-600
Number of pages13
JournalGastro Hep Advances
Volume2
Issue number4
DOIs
StatePublished - Jan 2023

Keywords

  • Abdominal Pain
  • Familial Adenomatous Polyposis
  • Gardner's Syndrome
  • Intestinal Transplantation

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