A Retrospective Study of the Role of Perioperative Serum Albumin and the Albumin–Bilirubin Grade in Predicting Post-Liver Transplant Length of Stay

Ryan Wang, Daniel Katz, Hung Mo Lin, Yuxia Ouyang, Jonathan Gal, Sumanth Suresh, Ismail Labgaa, Parissa Tabrizian, Samuel Demaria, Jeron Zerillo, Natalie K. Smith

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Introduction: Serum albumin’s association with liver transplant outcomes has been investigated with mixed findings. This study aimed to evaluate perioperative albumin level, independently and as part of the albumin–bilirubin (ALBI) grade, as a predictor of post-liver transplant hospital and intensive care unit (ICU) length of stay (LOS). Methods: Adult liver-only transplant recipients at our institution from September 2011 to May 2019 were included in this retrospective study. Repeat transplants were excluded. Demographic, laboratory, and hospital course data were extracted from an institutional data warehouse. Negative binomial regression was used to assess the association of LOS with ALBI grade, age, BMI, ASA score, Elixhauser comorbidity index, MELD-Na, warm ischemia time, units of platelets and cryoprecipitate transfused, and preoperative serum albumin. Results: Six hundred and sixty-three liver transplant recipients met inclusion criteria. The median preoperative serum albumin was 3.1 [2.6–3.6] g/dL. The median postoperative ICU and hospital LOS were 3.8 [2.4–6.8] and 12 [8–20] days, respectively. Preoperative serum albumin predicted hospital but not ICU LOS (ratio.9 [95% confidence interval (CI).84–.99], P =.03, hospital LOS vs ratio.92 [95% CI 0.84–1.02], P =.10, ICU LOS). For patients with MELD-Na ≤ 20, ALBI grade-3 predicted longer hospital and ICU LOS (ratio 1.40 [95% CI 1.18–1.66], P <.001, hospital LOS vs ratio 1.62 [95% CI 1.32–1.99], P <.001, ICU LOS). These associations were not significant for patients with MELD-Na > 20. Conclusions: Serum albumin predicted post-liver transplant hospital LOS. ALBI grade-3 predicted increased hospital and ICU LOS in low MELD-Na recipients.

Original languageEnglish
Pages (from-to)16-24
Number of pages9
JournalSeminars in Cardiothoracic and Vascular Anesthesia
Volume27
Issue number1
DOIs
StatePublished - Mar 2023

Keywords

  • length of stay
  • liver transplantation
  • serum albumin

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