A retrospective study of percutaneous endoscopic gastrostomy in ALS patients during the BDNF and CNTF trials

Edward J. Kasarskis, Debra Scarlata, Robert Hill, Cynthia Fuller, Nancy Stambler, Jesse M. Cedarbaum

Research output: Contribution to journalArticlepeer-review

124 Scopus citations

Abstract

Percutaneous endoscopic gastrostomy (PEG) provides a reliable route for nutrition and hydration in ALS patients with dysphagia. We performed a retrospective analysis of the CNTF and BDNF databases to determine the clinical status of ALS patients within 30 days preceding PEG insertion. This analysis revealed an approximately 50% reduction of function across multiple measures of ALS disease status. A trend to earlier intervention with PEG was apparent upon review of published studies and the CNTF and BDNF studies. By comparing the rate of decline pre- and post-PEG, nutritional supplementation via PEG stabilized the weight loss experienced by patients. Death within 30 days post-PEG was associated with a marked reduction in forced vital capacity (FVC) and identified a group of ALS patients in whom PEG should be cautiously performed. These data emphasize the importance of sequential measurement of FVC in managing ALS patients to guide the timing of nutritional intervention with PEG.

Original languageEnglish
Pages (from-to)118-125
Number of pages8
JournalJournal of the Neurological Sciences
Volume169
Issue number1-2
DOIs
StatePublished - 31 Oct 1999
Externally publishedYes

Keywords

  • Amyotrophic lateral sclerosis
  • Percutaneous endoscopic gastrostomy

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