A resource of targeted mutant mouse lines for 5,061 genes

International Mouse Phenotyping Consortium (IMPC)

doi:10.1038/s41588-021-00825-y

A resource of targeted mutant mouse lines for 5,061 genes

International Mouse Phenotyping Consortium (IMPC)

Research output: Contribution to journal › Comment/debate

66 Scopus citations

Original language	English
Pages (from-to)	416-419
Number of pages	4
Journal	Nature Genetics
Volume	53
Issue number	4
DOIs	https://doi.org/10.1038/s41588-021-00825-y
State	Published - Apr 2021
Externally published	Yes

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10.1038/s41588-021-00825-y

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@article{e1d6ee4c0cdd487e809a33d6ee21f976,

title = "A resource of targeted mutant mouse lines for 5,061 genes",

author = "{International Mouse Phenotyping Consortium (IMPC)} and Birling, {Marie Christine} and Atsushi Yoshiki and Adams, {David J.} and Shinya Ayabe and Beaudet, {Arthur L.} and Joanna Bottomley and Allan Bradley and Brown, {Steve D.M.} and Antje B{\"u}rger and Wendy Bushell and Francesco Chiani and Chin, {Hsian Jean Genie} and Skevoulla Christou and Codner, {Gemma F.} and DeMayo, {Francesco J.} and Dickinson, {Mary E.} and Brendan Doe and Donahue, {Leah Rae} and Fray, {Martin D.} and Alessia Gambadoro and Xiang Gao and Marina Gertsenstein and Alba Gomez-Segura and Goodwin, {Leslie O.} and Heaney, {Jason D.} and Yann H{\'e}rault and {de Angelis}, {Martin Hrabe} and Jiang, {Si Tse} and Justice, {Monica J.} and Petr Kasparek and King, {Ruairidh E.} and Ralf K{\"u}hn and Ho Lee and Lee, {Young Jae} and Zhiwei Liu and Lloyd, {K. C.Kent} and Isabel Lorenzo and Mallon, {Ann Marie} and Colin McKerlie and Meehan, {Terrence F.} and Fuentes, {Violeta Munoz} and Stuart Newman and Nutter, {Lauryl M.J.} and Oh, {Goo Taeg} and Guillaume Pavlovic and Ramiro Ramirez-Solis and Barry Rosen and Ryder, {Edward J.} and Santos, {Luis A.} and Roland Friedel",

note = "Funding Information: We thank all technical personnel at the different centers involved in this project for their contributions. We thank G. Clarke for support with illustrations. M.-C.B., G.P., M.W.-D., Y.H. and T.S. were supported by the Universit{\'e} de Strasbourg, the CNRS, the INSERM and the {\textquoteleft}Investissements d'avenir{\textquoteright} programs (ANR-10-IDEX-0002-02, ANR-10-LABX-0030-INRT and ANR-10-INBS-07 PHENOMIN); A.Y. and M.T. were supported by a RIKEN BioResource Research Center (BRC), Management Expenses Grant from the Ministry of Education, Culture, Sports, Science and Technology (MEXT); D.A., J.B., A. Bradley, W.B., B.D., S.N., R.R.S., B.R., E.R., W.S., K.S. and H.W.-J. were supported by the Wellcome Trust; S.B., S.C., G.C., M.F., S.W. and L.T. were supported by the Medical Research Council (A410); M.G., C.M. and L.N. were supported by Genome Canada and Ontario Genomics (OGI-051); H.L., Y.J.L., G.T.O. and J.K.S. were supported by the National Research Foundation (2014M3A9D5A01074636, 2014M3A9D5A01075128 and 2013M3A9D5072550), Republic of Korea (KMPC); M.B., A. Bradley, S.B., A. B{\"u}rger, W.B., F.C., M.F., A.G., M.H.d.A., R.K., S.N., G.P., R.R.S., B.R., E.R., J.S., W.S., C.S., T.S., G.T.-V., S.W., W.W. and L.T. were supported by the European Commission (EUCOMM (LSHM-CT-2005-018931), EUCOMMTOOLS (FP7-HEALTH-F4-2010-261492), EUMODIC, Infrafrontier 01KX1012 (M.H.d.A.) and EU Horizon 2020: IPAD-MD funding 653961 (M.H.d.A.)); R.S. and P.K. were supported by RVO 68378050 from the Academy of Sciences of the Czech Republic and by LM2015040 and LM2018126 (Czech Centre for Phenogenomics), CZ.1.05/2.1.00/19.0395 and CZ.1.05/1.1.00/02.0109 funded by the Ministry of Education, Youth and Sports and the European Regional Development Fund. Work was supported by the National Key R&D Program of China 2018YFA0801100 to Y.X. Research reported in this publication was supported by the NIH Common Fund, the Office of The Director and the National Human Genomic Research Institute of the National Institutes of Health (U42OD011174 supported A.L.B., J.B., A. Bradley, W.B., B.D., M.D., M.F., J. H., M.J., I.L., F.M., S.N., R.R.S., B.R., E.R., W.S., J.S., S.W. and L.T.; U42OD011175 supported M.G., C.M., L.N., B.W., J.W. and K.C.L.; U42OD011185 supported L.R.D., L.G., M.V.W. and S.A.M.; U54HG006370-02 supported A.G.-S., R.E.K., A.-M.M., T.M., V.M.F. and L.S.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.",

year = "2021",

month = apr,

doi = "10.1038/s41588-021-00825-y",

language = "English",

volume = "53",

pages = "416--419",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - A resource of targeted mutant mouse lines for 5,061 genes

AU - International Mouse Phenotyping Consortium (IMPC)

AU - Birling, Marie Christine

AU - Yoshiki, Atsushi

AU - Adams, David J.

AU - Ayabe, Shinya

AU - Beaudet, Arthur L.

AU - Bottomley, Joanna

AU - Bradley, Allan

AU - Brown, Steve D.M.

AU - Bürger, Antje

AU - Bushell, Wendy

AU - Chiani, Francesco

AU - Chin, Hsian Jean Genie

AU - Christou, Skevoulla

AU - Codner, Gemma F.

AU - DeMayo, Francesco J.

AU - Dickinson, Mary E.

AU - Doe, Brendan

AU - Donahue, Leah Rae

AU - Fray, Martin D.

AU - Gambadoro, Alessia

AU - Gao, Xiang

AU - Gertsenstein, Marina

AU - Gomez-Segura, Alba

AU - Goodwin, Leslie O.

AU - Heaney, Jason D.

AU - Hérault, Yann

AU - de Angelis, Martin Hrabe

AU - Jiang, Si Tse

AU - Justice, Monica J.

AU - Kasparek, Petr

AU - King, Ruairidh E.

AU - Kühn, Ralf

AU - Lee, Ho

AU - Lee, Young Jae

AU - Liu, Zhiwei

AU - Lloyd, K. C.Kent

AU - Lorenzo, Isabel

AU - Mallon, Ann Marie

AU - McKerlie, Colin

AU - Meehan, Terrence F.

AU - Fuentes, Violeta Munoz

AU - Newman, Stuart

AU - Nutter, Lauryl M.J.

AU - Oh, Goo Taeg

AU - Pavlovic, Guillaume

AU - Ramirez-Solis, Ramiro

AU - Rosen, Barry

AU - Ryder, Edward J.

AU - Santos, Luis A.

AU - Friedel, Roland

N1 - Funding Information: We thank all technical personnel at the different centers involved in this project for their contributions. We thank G. Clarke for support with illustrations. M.-C.B., G.P., M.W.-D., Y.H. and T.S. were supported by the Université de Strasbourg, the CNRS, the INSERM and the ‘Investissements d'avenir’ programs (ANR-10-IDEX-0002-02, ANR-10-LABX-0030-INRT and ANR-10-INBS-07 PHENOMIN); A.Y. and M.T. were supported by a RIKEN BioResource Research Center (BRC), Management Expenses Grant from the Ministry of Education, Culture, Sports, Science and Technology (MEXT); D.A., J.B., A. Bradley, W.B., B.D., S.N., R.R.S., B.R., E.R., W.S., K.S. and H.W.-J. were supported by the Wellcome Trust; S.B., S.C., G.C., M.F., S.W. and L.T. were supported by the Medical Research Council (A410); M.G., C.M. and L.N. were supported by Genome Canada and Ontario Genomics (OGI-051); H.L., Y.J.L., G.T.O. and J.K.S. were supported by the National Research Foundation (2014M3A9D5A01074636, 2014M3A9D5A01075128 and 2013M3A9D5072550), Republic of Korea (KMPC); M.B., A. Bradley, S.B., A. Bürger, W.B., F.C., M.F., A.G., M.H.d.A., R.K., S.N., G.P., R.R.S., B.R., E.R., J.S., W.S., C.S., T.S., G.T.-V., S.W., W.W. and L.T. were supported by the European Commission (EUCOMM (LSHM-CT-2005-018931), EUCOMMTOOLS (FP7-HEALTH-F4-2010-261492), EUMODIC, Infrafrontier 01KX1012 (M.H.d.A.) and EU Horizon 2020: IPAD-MD funding 653961 (M.H.d.A.)); R.S. and P.K. were supported by RVO 68378050 from the Academy of Sciences of the Czech Republic and by LM2015040 and LM2018126 (Czech Centre for Phenogenomics), CZ.1.05/2.1.00/19.0395 and CZ.1.05/1.1.00/02.0109 funded by the Ministry of Education, Youth and Sports and the European Regional Development Fund. Work was supported by the National Key R&D Program of China 2018YFA0801100 to Y.X. Research reported in this publication was supported by the NIH Common Fund, the Office of The Director and the National Human Genomic Research Institute of the National Institutes of Health (U42OD011174 supported A.L.B., J.B., A. Bradley, W.B., B.D., M.D., M.F., J. H., M.J., I.L., F.M., S.N., R.R.S., B.R., E.R., W.S., J.S., S.W. and L.T.; U42OD011175 supported M.G., C.M., L.N., B.W., J.W. and K.C.L.; U42OD011185 supported L.R.D., L.G., M.V.W. and S.A.M.; U54HG006370-02 supported A.G.-S., R.E.K., A.-M.M., T.M., V.M.F. and L.S.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

PY - 2021/4

Y1 - 2021/4

UR - http://www.scopus.com/inward/record.url?scp=85104162438&partnerID=8YFLogxK

U2 - 10.1038/s41588-021-00825-y

DO - 10.1038/s41588-021-00825-y

M3 - Comment/debate

C2 - 33833456

AN - SCOPUS:85104162438

SN - 1061-4036

VL - 53

SP - 416

EP - 419

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -